V. Lam

A Self-Supervised Learning Approach for High Throughput and High Content Cell Segmentation

This paper introduces a self-supervised learning method for cell segmentation that outperforms Cellpose in accuracy and reduces reliance on labeled data and computational expertise.

Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase

The paper presents the structure of yeast CPT1 in multiple substrate-bound states to elucidate the mechanism of phospholipid synthesis and selectivity.

Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis

This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.

A highly sensitive LC-MS/MS method for quantitative determination of 7 vitamin D metabolites in mouse brain tissue

This paper develops a sensitive LC-MS/MS method to quantify seven vitamin D metabolites in mouse brain tissue, achieving low limits of detection and high precision.

Plasma amyloid-β homeostasis is associated with Body Mass Index and weight-loss in people with overweight and obesity

This study examines the relationship between BMI, weight loss, and plasma amyloid-β homeostasis in individuals with overweight and obesity, finding that obesity is linked to lower Aβ42/40 ratios, but weight loss has minimal impact on these markers.

The effects of chronic consumption of lipid-rich and delipidated bovine dairy milk on brown adipose tissue volume in wild-type mice

This study examines how chronic consumption of lipid-rich and delipidated bovine dairy milk affects brown adipose tissue volume in mice on high-fat or low-fat diets.

Targeted, collaborative biodiversity conservation in the global ocean can benefit fisheries economies

The paper shows that collaborative marine protected areas can reduce economic losses and benefit fisheries globally.

A modular platform for engineering function ofnatural and synthetic biomolecular condensates

The paper identifies design principles for biomolecular condensates using PopZ and applies them to create synthetic condensates in human cells.

Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

This study shows that keratin 19 maintains E-cadherin at the cell surface, stabilizes cell-cell adhesion, and influences migration and colony formation in MCF7 cells.