imaging

Restoration of (nor)adrenergic-like Ca2+ signalling counteracts age-related motor decline

The paper shows that restoring noradrenergic-like Ca2+ signaling in aged Drosophila improves motor function and lifespan by enhancing metabolic responses.

Imputation-Based Harmonization Mitigates Site Effects Without Data Leakage in Machine Learning Studies

The paper introduces MIRTH, an imputation-based harmonization method that mitigates site effects in neuroimaging data without data leakage, achieving high predictive accuracy in machine learning studies.

Structural integrity moderates the cognitive bearing of dopamine clearance in aging

The paper develops ADAM, a model linking dopamine clearance and structural connectivity to cognitive aging, finding elevated clearance timescales and a structure-age-dependent association with cognitive performance.

Build it, But Did They Come? Monitoring Winter Feeding Stations Use by Endangered Long-tailed Gorals

The paper assesses how environmental and demographic factors influence feeding behavior of endangered long-tailed gorals at winter supplementary feeding stations.

Behavioral characterization of dynamic facial expression perception in rhesus monkeys (Macaca mulatta) using naturalistic and synthetic stimuli

This study shows rhesus monkeys can categorize facial expressions and generalize to novel stimuli, with performance influenced by expression components and signaler characteristics.

Unmasking Early Hepatorenal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen

This paper develops a collagen-targeting MRI contrast agent to noninvasively detect early fibrosis in ADPKD, showing improved detection compared to standard agents.

Predicting recovery trajectories and injury severity following partial crush spinal cord injury in mice

This paper predicts recovery trajectories and injury severity after partial crush spinal cord injury in mice using behavioral data and statistical modeling.

Fear Learning Induced Brain Dynamics Predict Individual Extinction Memory Expression following Transcranial Magnetic Stimulation

The paper shows that fear learning reorganizes brain activity, and this reorganization predicts extinction memory expression when modulated by TMS during extinction learning.

Extended amygdala function is governed by threat probability, not uncertainty

The paper challenges the canonical model of anxiety by showing that threat probability, not uncertainty, is more strongly associated with threat anticipation and EA regions.

Asymmetric Adaptation of Catch-up Saccades with Artificial Central Scotomas

The paper studies how catch-up saccades adapt in individuals with simulated central vision loss over five days of visual tracking.

Slide-level batch structure limits histology-guided supervision of transcriptomic foundation models

This paper investigates whether histology can improve transcriptomic foundation models by providing cross-modal supervision, but finds limited benefits due to slide-specific structure in gene-expression embeddings.

Formation of a swelling gel underlies a morphological transition in Bacillus subtilis biofilms

This study shows Bacillus subtilis biofilms use polymer composition to drive gel formation and morphological transitions through swelling and cross-linking.

An information-borrowing Bayesian method for inferring high-dimensional population-level brain connectivity from small samples

The paper introduces a Bayesian method for estimating population-level brain connectivity from small samples, showing improved accuracy over existing methods in simulations and real data.

A Novel Phenotyping Approach for Reconciling Precision and Variance in Disease Severity Estimates from High-resolution Imaging

The paper develops an imaging approach to improve disease severity estimation in wheat by combining high-resolution imaging and focus bracketing, reducing measurement uncertainty and enabling efficient sampling.

Ref(2)P/p62 protein pleomorphism confers tissue-specific function

One Drosophila Ref(2)P polypeptide takes different structures in midgut and muscle, driving autophagy or mitochondria-associated degradation; deleting disordered region IDR2 switches muscle Ref(2)P to midgut state.

Shared symmetry detection with divergent temporal dynamics in marmosets and humans

This study compares symmetry perception dynamics between marmosets and humans using non-invasive electrophysiology, finding conserved fast processing but reduced sustained processing in marmosets.

High-Throughput Morphological Profiling of Patient-Derived Human Liver Organoids for Hepatotoxicity Hazard Identification and Compound Prioritization

This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.

Plunge freezing tweezers with ultrasonic excitation for reducing preferred particle orientation in cryo-EM

This paper introduces a method using ultrasonic excitation in plunge freezing tweezers to reduce preferred particle orientation in cryo-EM, achieving a complete reconstruction of hemagglutinin at 2.5 Å resolution.

Biology-guided machine learning for robust anatomical correspondence across biodiversity datasets

This paper introduces a biology-guided machine learning method for automated anatomical landmark transfer across diverse biological datasets, showing significant improvements in accuracy and robustness under severe perturbations.

Gag proteolysis drives HIV-1 envelope conformational closure through the gp41 cytoplasmic tail

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

Toll-like receptor expression across histological states of Epidermodysplasia Verruciformis

The paper compares TLR3, TLR4, TLR5, and TLR9 expression across histological states in EV using immunohistochemistry and statistical analysis.

Local ROS and inefficient autophagosome formation limit Optineurin-mediated mitophagy in neurons

In rat hippocampal neurons under mild oxidative stress, Optineurin-marked damaged mitochondria are engulfed slowly and reach lysosomes over days; scavenging mitochondrial reactive oxygen species or nutrient deprivation speeds this.

Z-DNA Reveals a Conformational Dimension of Neutrophil Extracellular Trap Organization

This study identifies Z-DNA as a dynamic component of neutrophil extracellular traps (NETs) that influences their architecture, persistence, and immunostimulatory activity.

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

InsectDCT: A generalized pipeline for detection, taxonomic classification, and tracking of insects in camera-trap recordings

InsectDCT detects, classifies, and tracks insects in camera-trap footage using deep learning, achieving high accuracy in complex environments.

Environmental control of morphological color changes in the Bigfin Reef Squid, Sepioteuthis lessoniana

This study shows that environmental conditions and age influence chromatophore density and size in squid, revealing a trade-off between number and expansion of color cells.

Spontaneous behavior predicts colony membership, individual identity, and rank in naked mole-rat societies

Piloting floral-visitor assemblages: Camera-based monitoring in the cliff-dwelling Eastern Alpine endemic Physoplexis comosa (Campanulaceae)

This study tests a camera-based monitoring system to observe floral visitors of Physoplexis comosa across elevational gradients, revealing technical feasibility and elevational variation in visitor assemblages.

Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions

The paper investigates how alignment with female-typical brain functional connectivity patterns relates to mood disorders and neurodegenerative conditions, finding overlaps with gene expression profiles linked to sex hormones and disease.

Impact of noise on optical redox ratio estimation

This paper quantifies ORR estimation error in low-photon count data and provides an analytical solution validated with simulations and experiments.