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This study identifies TACAN as a PKD2 inhibitor that modulates its channel activity and mechano sensitivity in renal cells and zebrafish.

This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.

Low-frequency ultrasound rejuvenates senescent cells by reversing 15 characteristics, including autophagy activation and reduced SASP secretion, improving healthspan in mice.

This study shows that gut microbiota differentially regulate renal gene expression in a sex- and tissue-specific manner in mice.

The paper develops a mathematical model of ion homeostasis and cell volume regulation, showing how ion transporters and impermeant molecules influence steady-state conditions and energy efficiency.

This study uses a computational model to analyze how blood flow and vascular morphology interact in zebrafish microvessels under hemodynamic stress.

The paper investigates how T1R receptors modulate ER calcium dynamics in airway epithelial cells and shows amino acids reduce ER Ca2+ content and downstream apoptosis signaling.

This study uses a computational model to examine how hydroxychloroquine affects atrial electrophysiology in wild-type and PITX2+/- atrial cardiomyocytes, finding no significant arrhythmogenic effects at therapeutic concentrations but potential risks at higher doses.

This study identifies SLC25A47 as a liver-specific mitochondrial carrier that regulates gluconeogenesis and energy expenditure by controlling pyruvate flux and FGF21 expression.

The paper develops a flow cytometry protocol to rapidly profile phenotypic traits of endosymbiotic dinoflagellates at the single-cell level.

This study identifies RSK as the kinase responsible for AQP2 S256 phosphorylation and membrane trafficking induced by erlotinib, distinct from the VP-PKA pathway.

This study identifies AMPKγ1 complex activity as a marker of health and longevity, showing its decline with age and association with frailty in humans and killifish.

This study uses computational models to show sex and time-of-day differences in diuretic effects, with loop diuretics showing larger effects during the active phase and K+-sparing diuretics showing sex-specific time differences.

Breathe Easy automates respiratory data analysis, producing statistical outputs and graphs, validated against manual methods in an Alzheimer's mouse model.

This study evaluates the effect of potassium nitrate and calcium chloride priming on Honesty seed germination and seedling growth, finding that 1% KNO3 maximizes invigoration.

The paper shows that forskolin and ATP synergistically increase DRA activity in intestinal epithelial cells through intracellular Ca2+ elevation, which is blocked by BAPTA-AM.

This study shows that dietary sugar and protein oppositely regulate Dilp2 and Dilp6 in Drosophila larvae, affecting growth and metabolism through distinct mechanisms.

This study shows that Yap and Wwtr1 regulate Ccn3 in cardiac myofibroblasts, and their depletion reduces fibrosis and improves cardiac function after myocardial infarction.