A. Tam

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies

The paper develops a transfer learning approach to identify senescent cells across species and tissues using an in vivo-derived gene expression signature, revealing conserved and tissue-specific senescence features.

Dormant spores sense amino acids through the B subunits of their germination receptors

The paper identifies GerAB as the L-alanine sensor in spores, showing mutations in its ligand-binding pocket impair germination and substitutions enable response to other amino acids.

Warming in the land of the midnight sun: breeding birds may suffer greater heat stress at high- vs low-Arctic sites

This study predicts the temperature threshold for snow bunting breeding performance and finds high-Arctic sites experience more severe heat stress than low-Arctic sites due to prolonged periods of exceeding the critical temperature.

Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicities

This study shows that engineering NK cells to secrete IL15 improves their anti-AML activity but causes systemic toxicities.

A landscape of synergistic drug combinations in non-small-cell lung cancer

The paper identifies synergistic drug combinations in non-small-cell lung cancer cell lines, finding that synergy often arises from sensitizing resistant models through dual pathway targeting.

Single cell RNA-seq in regenerative and fibrotic biomaterial environments defines new macrophage subsets

The paper uses single-cell RNA sequencing to identify distinct macrophage subsets in regenerative and fibrotic environments, revealing new phenotypes and potential therapeutic targets.

Interleukin 17 and senescence regulate the foreign body response

This study identifies IL17 and senescence as regulators of the foreign body response, showing their roles in fibrosis and potential as therapeutic targets.

Solid State High Throughput Screening Microscopy

The paper introduces a solid state high throughput screening microscopy system that captures images of multiple spatially separated samples rapidly and efficiently without mechanical movement.