J. Kirk

Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation

This study identifies proteolytic degradation of atrial sarcomere proteins as a mechanism underlying contractile defects in atrial fibrillation.

Cochlear implant material effects on inflammatory cell function and foreign body response

This study examines how cochlear implant materials affect macrophage and fibroblast function and fibrous tissue growth, finding greater fibrosis and bone formation around platinum compared to PDMS.

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

This study shows reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer by promoting DNA hypermethylation and neuroendocrine gene expression.

Yeast Chd1p remodels nucleosomes with unique DNA unwrapping and translocation dynamics

This study uses single-molecule techniques to show that yeast CHD1 remodels nucleosomes through unique DNA unwrapping and translocation dynamics involving ATP binding and hydrolysis.

Dysregulated Alternative Splicing Landscape Identifies Intron Retention as a Hallmark and Spliceosome as a Therapeutic Vulnerability in Aggressive Prostate Cancer

The paper identifies intron retention as a hallmark of aggressive prostate cancer and highlights the spliceosome as a therapeutic target by analyzing splicing dysregulation across prostate cancer progression.

The miR-96 and RAR&gamma signaling axis governs androgen signaling and prostate cancer progression

This study identifies miR-96 as a regulator of RARγ expression, which in turn controls androgen signaling and prostate cancer progression through gene network alterations.