Author

C. You

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Plant Biology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2

Frequent Co-Authors

P. Xu· 3 shared H. E. Xu· 2 shared J. Piehler· 2 shared S. Huang· 2 shared X. Chen· 2 shared Y. Jiang· 2 shared Y. Zhang· 2 shared A. Plueckthun· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiophysics

P. Xu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture

h. ji, L. Yue, H. Sun, R. Chen, R. Zhou, A. Xiao, Y. Yang, R. Wang, C. You, Y. Liu

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

bioRxiv · Apr 6, 2023 · PreprintCell Biology

Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis

L. Fan, B. Gao, Y. Xu, N. Flynn, B. Le, C. You, S. Li, N. Achkar, P. A. Manavellae, X. Chen

This study identifies Arabidopsis AAR2 as a conserved splicing factor that also promotes miRNA biogenesis by interacting with HYL1 and regulating its dephosphorylation.

bioRxiv · Jun 26, 2022Plant Biology

Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

M. Philippi, C. P. Richter, M. Kappen, I. Watrinet, Y. Miao, M. Runge, L. Jorde, S. Korneev, M. Holtmannspoetter, R. Kurre, J. Holthuis, K. C. Garcia, A. Plueckthun, M. Steinhart, J. Piehler, C. You

The paper develops biofunctional nanodot arrays to study Wnt signalodroplets in live cells, revealing synergistic co-condensation through liquid-liquid phase separation.

bioRxiv · Jun 11, 2022Biophysics

Parallel analysis of RNA ends reveals global microRNA-mediated target RNA cleavage in maize

J. He, C. Xu, C. You, B. Mo, X. Chen, L. Gao, L. Liu

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

bioRxiv · Jun 2, 2022Plant Biology

Physiological and molecular mechanisms regulated mesophyll conductance under severe drought in water-saving drought-resistant rice

H. He, L. Wang, X. Zhang, N. Zhan, Q. Wang, R. Yang, C. You, J. Ke, L. Wu

This study identifies key genes regulating mesophyll conductance in drought-resistant rice under severe drought by comparing gene expression and photosynthetic processes between two rice cultivars.

bioRxiv · Mar 24, 2022 · PreprintPhysiology

Structural insights into the peptide selectivity and activation of human neuromedin U receptors

C. You, Y. Zhang, P. Xu, S. Huang, W. Yin, H. E. Xu, Y. Jiang

This study reports cryo-EM structures of NMUR1 and NMUR2 bound to NMU and NMS, revealing peptide selectivity mechanisms and activation principles for drug design.

bioRxiv · Feb 21, 2022Biophysics

Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex

S. Huang, p. Xu, Y. Tan, C. You, Y. Zhang, Y. Jiang, H. E. Xu

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

bioRxiv · May 29, 2021Biophysics

TIN2 facilitates TRF1-mediated trans- and cis-interactions on physiologically relevant long telomeric DNA

H. Pan, P. Kaur, M. Liu, P. Xu, C. Mahn, R. Barnes, Q. Tang, P. Hao, D. Bhattaram, C. You, J. Piehler, K. Weninger, R. Riehn, S. Smith, P. L. Opersko, H. Wang

This study shows TIN2 promotes TRF1-mediated DNA-DNA bridging on telomeres, stabilizing interactions that depend on telomere length and sequence.

bioRxiv · Sep 12, 2020 · PreprintBiophysics