D. Liang

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

The Unfolded Protein Response Sensor PERK Mediates Mechanical Stress-induced Maturation of Focal Adhesion Complexes in Glioblastoma Cells

This study shows that PERK mediates mechanical stress-induced maturation of focal adhesion complexes in glioblastoma cells by regulating F-Actin remodeling and FAC component expression.

Imaging and quantification of prostate cancer-associated bone by polarization-sensitive optical coherence tomography

This study uses PS-OCT to differentiate bone tissue types in prostate cancer metastases by analyzing collagen organization and quantifying structural features.

Distinct mechanisms drive plant-nitrifier interactions in topsoil and subsoil

This study investigates how a deep-rooted grass and a shallow-rooted grass influence nitrifier communities and nitrification rates in topsoil and subsoil through different mechanisms.

Imaging interorganelle phospholipid transport by extended synaptotagmins using bioorthogonally tagged lipids

The paper develops a method to visualize phospholipid transport between the plasma membrane and ER using bioorthogonal chemistry and extended synaptotagmins.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

Replication is the key barrier during the dual-host adaption of mosquito-borne flaviviruses

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

Rootstocks influence the response of ripening grape berries to leafroll associated viruses

This study shows that rootstocks influence how ripening grape berries respond to leafroll-associated viruses, with distinct effects observed across different infection conditions and developmental stages.

Brassinosteroid signaling component SlBES1 promotes tomato fruit softening through transcriptional repression of PMEU1

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

Deep learning-based adaptive detection of fetal nucleated red blood cells

This study develops an AI system to identify fetal nucleated red blood cells using deep learning, achieving high accuracy and sensitivity in testing.

Infection risk and extensive parental care govern the molecular evolution of Toll-like receptors in birds.

This study examines the molecular evolution of Toll-like receptor genes in birds, finding that positive selection is linked to migration, parental care, and body size.

Fine-scale position effects shape the distribution of inversion breakpoints in Drosophila melanogaster

The paper examines the fine-scale distribution of inversion breakpoints in Drosophila melanogaster and identifies factors influencing their fitness impacts.

Evaluating the Impact of Purifying Selection on Species-level Molecular Dating

This study evaluates how purifying selection affects species-level molecular dating by comparing branch lengths and time estimates across datasets with varying selective constraints.

The differential distribution of bacteria between cancerous and noncancerous ovarian tissues in situ

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.