C. Chang

The paper reconstitutes autophagy-related reactions and shows that a positive feedback loop between PI3KC3-C1 and WIPI2 accelerates LC3 lipidation.

This study shows obesity increases TH2 immunopathology by disrupting PPARγ in T cells, and TZDs can protect against this effect in obese mice.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

The paper identifies gene acquisitions in Xanthomonas vasicola pv. vasculorum genomes from the U.S. and Argentina, linking them to increased virulence through horizontal gene transfer, including a prophage from X. vasicola pv. holcicola.

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

This study identifies cardiac stromal progenitors as multipotent cells that contribute to fibrosis and arrhythmogenic cardiomyopathy under different pathological conditions.

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

This paper discusses the importance of mathematical modeling in plant morphology and outlines challenges and opportunities for integrating geometric and topological approaches in plant science research and education.

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.