S. Gnjatic

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis

This study identifies anti-integrin αvβ6 autoantibodies as a predictive biomarker for ulcerative colitis, showing they precede diagnosis by up to 10 years and correlate with adverse outcomes.

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

This study identifies shifts in lung macrophage composition linked to COVID-19 severity and recovery, suggesting therapeutic strategies targeting macrophage function.

Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition

Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages

This study shows HIV-1 infected macrophages transfer virus to renal epithelial cells, leading to proliferation and potential persistence of infection in the kidney.

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events

The paper identifies immune dysregulations in atherosclerotic plaques linked to ischemic cerebrovascular events using single-cell analyses of T cells and macrophages.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy