Author

W.-t. He

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Biochemistry· 1 Microbiology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:human· 5 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

G. Song· 9 shared R. Andrabi· 9 shared S. Callaghan· 8 shared D. Nemazee· 7 shared D. R. Burton· 7 shared L. Peng· 7 shared D. M. Smith· 6 shared F. Anzanello· 6 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

9 shared papersImmunology

G. Song

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

G. Song, M. Yuan, H. Liu, T. Capozzola, R. N. Lin, J. L. Torres, W.-t. He, R. Musharrafieh, K. Dueker, P. Zhou, S. Callaghan, N. Mishra, P. Yong, F. Anzanello, G. Avillion, , R. Andrabi

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

bioRxiv · Apr 26, 2023Immunology

A broad and potent neutralization epitope in SARS-related coronaviruses

M. Yuan, X. Zhu, W.-t. He, P. Zhou, C. I. Kaku, T. Capozzola, C. Y. Zhu, X. Yu, H. Liu, W. Yu, Y. Hua, H. Tien, L. Peng, G. Song, C. Cottrell, , I. A. Wilson

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

bioRxiv · Mar 13, 2022 · PreprintMicrobiology

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

P. Zhou, G. Song, W.-t. He, N. Beutler, L. V. Tse, D. R. Martinez, A. Schafer, F. Anzanello, P. Yong, L. Peng, K. Dueker, R. Musharrafieh, S. Callaghan, T. Capozzola, M. Yuan, , R. Andrabi

The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.

bioRxiv · Mar 4, 2022Immunology

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

W.-T. He, X. Hou, J. Zhao, J. Sun, H. He, W. Si, J. Wang, Z. Jiang, Z. Yan, G. Xing, M. Lu, M. A. Suchard, X. Ji, W. Gong, B. He, , S. Su

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

bioRxiv · Nov 10, 2021 · PreprintZoology

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

W.-t. He, R. Musharrafieh, G. Song, K. Dueker, L. V. Tse, D. R. Martinez, A. Schafer, S. Callaghan, P. Yong, N. Beutler, J. L. Torres, R. M. Volk, P. Zhou, M. Yuan, H. Liu, , R. Andrabi

This study isolates a panel of broadly neutralizing antibodies against SARS-like viruses from donors, showing effectiveness against multiple variants including Omicron.

bioRxiv · Sep 8, 2021Immunology

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

W.-t. He, M. Yuan, S. Callaghan, R. Musharrafieh, G. Song, M. Silva, N. Beutler, W.-H. Lee, P. Yong, J. L. Torres, M. Melo, P. Zhou, F. Zhao, X. Zhu, L. Peng, , R. Andrabi

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

bioRxiv · Jul 5, 2021Immunology

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

P. Zhou, M. Yuan, G. Song, N. Beutler, N. Shaabani, D. Huang, W.-t. He, X. Zhu, S. Callaghan, P. Yong, F. Anzanello, L. Peng, J. Ricketts, M. Parren, E. Garcia, , R. Andrabi

This study identifies a broadly neutralizing antibody that targets a conserved site on beta-coronavirus spike proteins and provides protection against SARS-CoV-2 infection.

bioRxiv · Mar 30, 2021Immunology

Site-specific steric control of SARS-CoV-2 spike glycosylation

J. D. Allen, H. Chawla, F. Samsudin, L. Zuzic, A. T. Shivgan, Y. Watanabe, W.-T. He, S. Callaghan, G. Song, P. Yong, P. J. M. Brouwer, Y. Song, Y. Cai, H. M. E. Duyvesteyn, T. Malinauskas, , M. Crispin

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

bioRxiv · Mar 8, 2021 · PreprintBiochemistry

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

G. Song, W.-t. He, S. Callaghan, F. Anzanello, D. Huang, J. Ricketts, J. L. Torres, N. Beutler, L. Peng, S. Vargas, J. Cassell, M. Parren, L. Yang, C. Ignacio, D. M. Smith, , R. Andrabi

The paper examines cross-reactive serum and memory B cell responses to SARS-CoV-2 and endemic coronaviruses, finding weak serum cross-reactivity but stronger memory B cell cross-reactivity.

bioRxiv · Sep 22, 2020Immunology

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

T. F. Rogers, F. Zhao, D. Huang, N. Beutler, A. Burns, W.-t. He, O. Limbo, C. Smith, G. Song, J. Woehl, L. Yang, R. K. Abbott, S. Callaghan, E. Garcia, J. Hurtado, , D. Burton

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

bioRxiv · May 11, 2020Immunology