T. Hou

Exenatide administration time determines the effects on blood pressure dipping in db/db mice via modulation of food intake and sympathetic activity

This study shows that exenatide administration time affects blood pressure dipping in db/db mice by altering food intake and sympathetic activity, with efficacy dependent on food availability and circadian timing.

The pioneer transcription factor ELF2 remodels the nucleosome near transcription start sites

This study reveals how ELF2, a pioneer transcription factor, remodels nucleosomes near transcription start sites by unwrapping DNA and exposing chromatin, facilitating transcription initiation.

Variant Surface Protein GP60 Contributes to Host Infectivity of Cryptosporidium parvum

The paper investigates the role of GP60 in Cryptosporidium parvum infectivity, finding that while GP60 is not essential, its cleavage products affect parasite growth and infection severity.

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

The study identifies SKSR1 as a key virulence factor in Cryptosporidium by crossing isolates with different virulence and analyzing genetic loci associated with infectivity.

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancers

The paper introduces MaGIC, a ctDNA profiling method that improves cancer classification and chemosensitivity prediction by reducing background noise from cfDNA.

Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers

This study identifies lncRNA152 as an angiogenesis-inhibiting tumor suppressor in TNBC that upregulates RBM47, reducing cancer aggressiveness.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Active Time-Restricted Feeding Protects the Blood Pressure Circadian Rhythm in Diabetic Mice

This study shows that time-restricted feeding prevents nondipping blood pressure in diabetic mice by restoring circadian rhythms through mechanisms involving BMAL1 and sympathetic vascular tone.

A physics-based energy function allows the computational redesign of a PDZ domain

This paper redesigns a PDZ domain using a physics-based energy function, showing that sequences generated by Monte Carlo simulations can fold into the correct structure and bind ligands.