D. Lai

Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.

Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells

This paper develops a human heart-on-a-chip model using iPSC-derived cardiomyocytes, fibroblasts, and vascular endothelial cells, showing improved cardiac function and responses similar to in vivo hearts.

Multi-omics map revealed PPARalpha activation protecting against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis

The paper identifies PPARalpha activation as protective against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis, using multi-omics data from rat hearts.

Evolutionary tracking of cancer haplotypes at single-cell resolution

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

The impact of mutational processes on structural genomic plasticity in cancer cells

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

Skin protective effects of RM191A, a novel superoxide dismutase mimetic

This study evaluates RM191A, a novel SOD mimetic, showing enhanced antioxidant activity and protective effects against UV-induced DNA damage and inflammation in skin models.

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.

Quantitative LCMS for ceramides/dihydroceramides: pregnancy baseline biomarkers and potential metabolic messengers

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.