Author

E. C. Garner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11 Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:bacteria (other)· 7 Research Focus:cell type annotation· 7 Research Focus:cell signaling & trafficking· 6 Approach:microscopy & imaging analysis· 5 Approach:genetic perturbation / CRISPR· 4 Research Focus:differential expression· 3 Assay:fluorescence / live-cell microscopy· 3

Frequent Co-Authors

S. Wilson· 4 shared C. L. Dulberger· 3 shared E. J. Rubin· 3 shared G. R. Squyres· 3 shared A. Schmid· 2 shared A. W. Murray· 2 shared J. Ryan· 2 shared J. Zheng· 2 shared

Activity by Year

2018-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersMicrobiology

S. Wilson

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

Axial asymmetry organizes division plane orthogonality in Neisseria gonorrhoeae

A. C. Bandekar, D. A. Ramirez-Diaz, S. G. Palace, Y. Wang, E. C. Garner, Y. H. Grad

This study shows that axial asymmetry in Neisseria gonorrhoeae guides orthogonal division planes, maintaining diplococcal morphology through ParB segregation and MinCDE system function.

bioRxiv · Jun 28, 2024 · PreprintMicrobiology

Processive movement of Staphylococcus aureus essential septal peptidoglycan synthases is independent of FtsZ treadmilling and drives cell constriction

S. Schaeper, A. D. Brito, B. M. Saraiva, G. R. Squyres, M. J. Holmes, E. C. Garner, Z. Hensel, R. Henriques, M. G. Pinho

This study shows that FtsW/PBP1 and DivIB move processively around the division site in S. aureus, driving cell constriction independently of FtsZ treadmilling.

bioRxiv · Jun 29, 2023Microbiology

Salactin, a dynamically unstable actin homolog in Haloarchaea

J. Zheng, A. Lammers, J. Mallon, T. Litschel, E. Moody, D. A. R. Diaz, A. Schmid, T. A. Williams, A. Bisson, E. C. Garner

This study identifies and characterizes Salactin, an actin homolog in Haloarchaea, showing it forms dynamically unstable filaments and is involved in chromosomal segregation under low-ploidy conditions.

bioRxiv · Mar 9, 2023Microbiology

Tuberculosis treatment failure associated with evolution of antibiotic resilience

Q. Liu, J. Zhu, C. L. Dulberger, S. Stanley, S. Wilson, E. S. Chung, X. Wang, P. Culviner, Y. J. Liu, N. D. Hicks, G. H. Babunovic, S. R. Giffen, B. B. Aldridge, E. C. Garner, E. J. Rubin, , S. M. Fortune

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

bioRxiv · Mar 29, 2022Microbiology

Antibiotic action revealed by real-time imaging of the mycobacterial membrane

M. G. Wuo, C. L. Dulberger, R. A. Brown, A. Sturm, E. Ultee, Z. Bloom-Ackermann, C. Choi, E. C. Garner, A. Briegel, D. T. Hung, E. J. Rubin, L. L. Kiessling

This study uses real-time imaging to observe how antibiotics affect mycobacterial cell envelope remodeling, revealing unique cellular responses and extracellular vesicle production.

bioRxiv · Jan 7, 2022 · PreprintMicrobiology

Transcriptomic analysis of pathways associated with alpha(v) integrin-related non-canonical autophagy in human B cells

S. Sagadiev, V. Muir, E. Suchland, I. MEITLIS, N. Giltiay, J. Tam, E. C. Garner, C. Wivagg, D. Shows, R. James, A. Lacy-Hulbert, M. Acharya

The paper investigates the role of non-canonical autophagy in human B cells, showing it is induced in specific sub-populations and influences activation pathways.

bioRxiv · Aug 2, 2021 · PreprintImmunology

An Exhaustive Multiple Knockout Approach to Understanding Cell Wall Hydrolase Function in Bacillus subtilis

S. Wilson, R. K. J. Tank, J. K. Hobbs, S. j. Foster, E. C. Garner

This paper identifies the minimal set of cell wall hydrolases required for growth in Bacillus subtilis by creating a strain lacking 40 hydrolases, showing that only two remain essential.

bioRxiv · Feb 18, 2021 · PreprintMicrobiology

PrkC modulates MreB filament density and cellular growth rate by monitoring cell wall precursors

Y. Sun, E. C. Garner

The serine/threonine kinase PrkC modulates both MreB filament density and cellular growth rate by sensing lipid II in Bacillus subtilis.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism

J. W. McCausland, X. Yang, G. R. Squyres, Z. Lyu, K. E. Bruce, M. M. Lamanna, B. W. Söderström, E. C. Garner, M. E. Winkler, J. Xiao, J. Liu

This study shows FtsZ treadmilling drives directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism, controlling enzyme processivity and sPG synthesis.

bioRxiv · Jul 17, 2020Biophysics

Prophage-encoded phage defence proteins with cognate self-immunity

S. V. Owen, N. Wenner, C. L. Dulberger, E. V. Rodwell, A. Bowers-Barnard, N. Quinones-Olvera, D. J. Rigden, E. J. Rubin, E. C. Garner, M. Baym, J. C. D. Hinton

The paper identifies BstA, a prophage-encoded phage defense protein that suppresses phage epidemics through abortive infection, with self-immunity mediated by the anti-BstA element.

bioRxiv · Jul 13, 2020Microbiology

Dynamics of bacterial cell division: Z ring condensation is essential for cytokinesis

G. R. Squyres, M. J. Holmes, S. R. Barger, B. R. Pennycook, J. Ryan, V. T. Yan, E. C. Garner

The paper investigates the role of FtsZ binding proteins in bacterial cytokinesis, finding that Z ring condensation is essential for cell division.

bioRxiv · Jun 30, 2020Microbiology

The ribbon-helix-helix domain proteins CdrS and CdrL regulate cell division in archaea

C. L. Darnell, J. Zheng, S. Wilson, R. M. Bertoli, A. W. Bisson-Filho, E. C. Garner, A. Schmid

This study identifies and characterizes the CdrSL gene regulatory network in archaea, showing its role in regulating cell division through transcriptional control of FtsZ2.

bioRxiv · Jun 16, 2020 · PreprintMicrobiology

Bet hedging buffers budding yeast against environmental instability

L. E. Bagamery, Q. A. Justman, E. C. Garner, A. W. Murray

The paper shows that budding yeast use bet hedging to adapt to environmental changes by maintaining subpopulations with different metabolic strategies.

bioRxiv · Apr 8, 2020 · PreprintCell Biology

Independent evolution of polymerization in the Actin ATPase clan regulates hexokinase activity

P. R. Stoddard, E. M. Lynch, D. P. Farrell, Q. A. Justman, A. M. Dosey, F. DiMaio, T. A. Williams, J. M. Kollman, A. W. Murray, E. C. Garner

Yeast glucokinase activity is limited by its polymerization, which is critical for cell viability during glucose refeeding.

bioRxiv · Jul 2, 2019 · PreprintBiochemistry

Cell Diameter in Bacillus subtilis is Determined by the Opposing Actions of Two Distinct Cell Wall Synthetic Systems

M. Dion, M. Kapoor, Y. Sun, S. Wilson, J. Ryan, A. Vigouroux, S. van Teeffelen, R. Oldenbourg, E. C. Garner

The paper investigates how two cell wall synthesis systems in Bacillus subtilis determine cell diameter through their opposing effects on growth and width.

bioRxiv · Aug 22, 2018Microbiology