S. Wilson

Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

This study shows that knocking down Hsd17b13 in obese mice reduces liver steatosis and improves liver health markers, suggesting HSD17B13 as a therapeutic target for MASLD.

Invasive traits of freshwater fish database (ITOFF)

The paper introduces the ITOFF database, which integrates data on freshwater fish invasions and life-history traits to show that classical trait-based predictions of invasion success are not reliable.

Multiplexed effector screening for recognition by endogenous resistance genes using positive defense reporters in wheat protoplasts

This paper develops a wheat protoplast assay for efficient screening of Avr/R gene interactions, enabling multiplexed testing and improved identification of defense responses.

Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in Schistosoma haematobium and Schistosoma mansoni infection

This paper characterizes the Tegument Allergen-Like (TAL) protein family in Schistosoma haematobium and shows cross-reactive IgE responses similar to those observed in S. mansoni infection.

Protected area planning to conserve biodiversity in an uncertain future

This study identifies priority areas for expanding the global protected area system to account for governance, land use, and climate risks while maximizing species protection.

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

Development of a polymicrobial checkerboard assay as a tool for determining combinatorial antibiotic effectiveness in polymicrobial communities

This paper develops a polymicrobial checkerboard assay to assess combinatorial antibiotic effectiveness in mixed bacterial communities, finding that visible turbidity is not reliable and polymicrobial interactions can reduce antibiotic efficacy.

Sustainable reference points for multispecies coral reef fisheries

The paper estimates sustainable reference points for multispecies coral reef fisheries using environmental data and assesses their status, finding that over half of jurisdictions have failed sustainability benchmarks.

Habitat protection and restoration: win-win opportunities for migratory birds in the Northern Andes

This study identifies opportunities where forest restoration and protection in Colombia align with migratory bird conservation, finding limited overlap between restoration areas and bird priority regions.

Tuberculosis treatment failure associated with evolution of antibiotic resilience

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

Balancing conservation priorities for grassland and forest specialist bird communities in agriculturally dominated landscapes

The paper identifies landscapes in eastern Ontario and southwestern Quebec that balance habitat needs of grassland and forest bird specialists through land cover diversity.

Cell-envelope synthesis is required for surface-to-mass coupling, which determines dry-mass density in Bacillus subtilis

The paper shows that surface-to-mass coupling determines dry-mass density in Bacillus subtilis by linking envelope synthesis to volume regulation.

An Exhaustive Multiple Knockout Approach to Understanding Cell Wall Hydrolase Function in Bacillus subtilis

This paper identifies the minimal set of cell wall hydrolases required for growth in Bacillus subtilis by creating a strain lacking 40 hydrolases, showing that only two remain essential.

Treeline ecotones shape the distribution of avian species richness and functional diversity in south temperate mountains

The paper examines how treeline ecotones influence avian species richness and functional diversity in the south temperate Andes by analyzing habitat structure and elevation effects.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.

The ribbon-helix-helix domain proteins CdrS and CdrL regulate cell division in archaea

This study identifies and characterizes the CdrSL gene regulatory network in archaea, showing its role in regulating cell division through transcriptional control of FtsZ2.

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development

This study analyzes RNA-seq data from Schistosoma mansoni during intra-mammalian development, identifying genes involved in immune evasion and adaptation to oxidative stress.

Extent of similarity between agricultural and natural land covers shapes how biodiversity responds to agricultural expansion at landscape scales

The study examines how ecosystem context influences biodiversity responses to agricultural expansion, finding that species diversity declines at lower agricultural extents in ecosystems with less similarity between natural and agricultural land covers.

Prioritize diversity or declining species? Trade-offs and synergies in spatial planning for the conservation of migratory birds in the face of land cover change

The paper evaluates trade-offs between conserving migratory bird diversity and decline hotspots, showing differing spatial priorities under various land cover change scenarios.

A library of cell-surface and secreted proteins from Schistosoma mansoni identifies early serological markers of infection

The paper identifies early serological markers of Schistosoma mansoni infection using a recombinant protein library and mouse infection time series.

Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening.

The paper demonstrates the use of bioprinted kidney organoids for high content drug screening, showing reproducibility and response to doxorubicin toxicity.

Optimizing the conservation of migratory species over their full annual cycle

This study evaluates land prioritization strategies for conserving migratory birds by comparing annual vs. weekly optimization and inclusion of human-dominated lands.

Cell Diameter in Bacillus subtilis is Determined by the Opposing Actions of Two Distinct Cell Wall Synthetic Systems

The paper investigates how two cell wall synthesis systems in Bacillus subtilis determine cell diameter through their opposing effects on growth and width.