B. Cheng

Hummingbirds rapidly respond to the removal of vision and control a sequence of rate-commanded maneuvers in milliseconds

This study shows hummingbirds control rapid flight maneuvers using rate-commanded movements and respond to vision loss after a critical time during escape sequences.

2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer

The paper shows nuclear rupture is common in cancer, especially glioblastoma, and links it to lamin proteins and immune signaling.

O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

Hummingbirds use wing inertial effects to improve maneuverability

This study identifies how hummingbirds use wing inertial effects to enhance maneuverability during flight by splitting wingbeat cycles into agility and stability phases.

SeMOE allows for quantitative glycan perception and exhibits anti-cancer potentiality

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

Liproxstatin-1 alleviates cartilage degradation by inhibiting chondrocyte ferroptosis in temporomandibular joint

This study shows that ferroptosis contributes to TMJOA cartilage degradation and that Lip-1 inhibits this process by reducing ferroptosis markers and oxidative stress in chondrocytes.

Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells

SEC-seq links cell secretions to transcriptomes, revealing VEGF-A secretion heterogeneity and a unique gene signature in MSCs with high secretion.

Targeting TR4-induced RCC cells-derived exosomally initiated signaling increases Sunitinib efficacy

This study shows TR4 promotes RCC cell-derived exosomal ADAM15, which activates EGFR in endothelial cells and reduces Sunitinib efficacy, and demonstrates that targeting this pathway enhances Sunitinib effectiveness.

Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses

This study shows that nuclear import of Gdown1 modulates global transcription and enhances cellular stress tolerance.

Three-dimensional actuation of hummingbird wings requires diverse effects from the primary flight muscles

This study develops a functional model of hummingbird musculoskeletal system to reveal how primary flight muscles generate three-dimensional wing actuation through diverse effects.

The noncoding RNA PRANCR regulates splicing of Fibronectin-1 to control keratinocyte proliferation and migration

This study identifies PRANCR as a lncRNA that regulates alternative splicing of FN1 to control keratinocyte proliferation and migration.

Counting of Enzymatically Amplified Affinity Reactions in Hydrogel Particle-Templated Drops

This paper presents a method to digitally count enzymatic reactions using hydrogel particle-templated drops, achieving femtomolar detection with standard equipment.

Efficient Inhibition of SARS-CoV-2 Using Chimeric Antisense Oligonucleotides through RNase L Activation

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

This study shows GSTZ1 enhances sorafenib-induced ferroptosis in HCC by inhibiting the NRF2/GPX4 axis, and its deficiency leads to resistance to sorafenib.

Recombinant SARS-CoV-2 RBD molecule with a T helper epitope as a built in adjuvant induces strong neutralization antibody response

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

Three dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval

This paper introduces a method to achieve high-precision 3D nanoscopy across whole cells and tissues by retrieving the in situ point spread function from single-molecule data.

Visual speed compensation of pitch-constrained blue-bottle flies under retinal-image velocity perturbation in a flight mill

This study examines how blue-bottle flies adjust their flight speed to maintain constant retinal-image velocity under perturbations in a flight mill.

Speed Control and Force-Vectoring of Blue Bottle Flies in a Magnetically-Levitated Flight Mill

This paper shows blue bottle flies use both body pitch and wing kinematics to control flight speed and force direction in a MAGLEV flight mill.