G. Liu

This study investigates how HMGB1 and RAGE promote tumor growth in autophagy-deficient livers by altering the tumor microenvironment and mitochondrial function.

The paper develops a modular toolbox of Stable Integration Vectors (SIV) for fission yeast to enable precise, stable genomic integration of heterologous sequences.

This paper introduces a machine learning method to design human IgG antibodies with superior target affinity and specificity, using high-throughput data without requiring target structural information.

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

The paper compares selection pressures on human genes in cancer and normal cells using mutation-profile-based methods, finding differences in selection pressures and their impact on cancer gene classification.