V. Viswanathan

Maladaptation in cereal crop landraces following a soot-producing climate catastrophe

This study assesses how landraces of four cereal crops would maladapt to soot-induced climate changes following a global catastrophe using climate models and genomic data.

Highly specific intracellular ubiquitination of a small molecule

The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

A superoxide reductase contributes to Clostridioides difficile resistance to oxygen

This study identifies a superoxide reductase (SOR) in C. difficile that contributes to its resistance to oxygen and oxidative stress.

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

The paper identifies ROS induction as a strategy to target MEK-inhibitor resistant NRAS-mutated melanoma cells by exploiting their quiescent metabolic state and elevated baseline ROS levels.

The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties

This study shows that SigL, an alternative sigma factor in C. difficile, affects toxin production, sporulation, and cell surface properties differently in two strains.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.