Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
J. Chen, B. Zhao, H. Dong, T. Li, X. Cheng, W. Gong, J. Wang, J. Zhang, G. Xin, Y. Yu, Y. Lei, J. Black, Z. Li, H. Wen
This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.
bioRxiv · Dec 14, 2023Cancer Biology