J. Dou

Synthetic bacterial consortium for degradation of plastic pyrolysis oil waste

This paper develops a synthetic bacterial consortium to degrade plastic pyrolysis oil waste, achieving high removal efficiencies for alkanes and aromatic hydrocarbons, and uses a neural network to model microbial activity.

Intrinsic epigenetic state of primary osteosarcoma drives metastasis

This study identifies chromatin activity differences in primary osteosarcoma tumors that correlate with metastatic potential and identifies genes involved in metastasis.

In situ genetically targeted chemical assembly of polymers on living neuronal membranes

The paper develops a method to genetically target polymer assembly on neuronal membranes to modify electrical properties with improved efficiency and biocompatibility.

The Trichloroethylene Metabolite S-(1,2-dichlorovinyl)-l-cysteine Inhibits Lipopolysaccharide-induced Transcriptomic Inflammation Pathways and Cytokine Secretion in a Macrophage Cell Model

This study shows DCVC inhibits LPS-induced inflammation and cytokine secretion in macrophages by downregulating key inflammatory pathways and genes.

ANTIBODY-INDEPENDENT ANTITUMOR EFFECTS OF CD32A-CHIMERIC RECEPTOR T CELLS: IMPLICATIONS FOR BREAST CANCER PROGNOSIS AND TREATMENT.

This study shows CD32A-chimeric receptor T cells can identify CD32A ligands, predict breast cancer sensitivity, and improve prognosis without antibodies.

Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus.

This study uses single-cell RNA sequencing to analyze how perinatal lead exposure affects hippocampal cell types in mice, finding increased oligodendrocytes and altered gene expression in specific cell clusters.

DNA methylation signature of smoking in lung cancer is enriched for exposure signatures in newborn and adult blood.

The paper identifies DNA methylation signatures of smoking in lung cancer and finds significant overlap with signatures in newborn and adult blood.