Author

J. Koff

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. C. Castaneda· 2 shared K. Palucka· 2 shared M. Schotsaert· 2 shared A. Choi· 1 shared A. Garcia-Sastre· 1 shared A. Korde· 1 shared A. Salner· 1 shared A. Williams· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

D. C. Castaneda

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evaluating Synergy of Clinically Utilized Phage OMKO1 with Five Antibiotics from Different Classes against Pseudomonas aeruginosa

Emma L. Kane, B. Chan, Dallas L. Mould, Kaitlyn E. Kortright, J. Koff, P. Turner

This study evaluates the synergy between phage OMKO1 and five antibiotics against Pseudomonas aeruginosa, showing reduced MIC and resistant regrowth in four of five combinations.

bioRxiv · Jan 14, 2026 · PreprintMicrobiology

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

Z. Harris, A. Korde, J. Khoury, E. Manning, G. Stanley, K. Mitchell, Y. Sun, B. Hu, H. J. Shin, J. Joerns, B. Clark, L. Placek, D. Unutmaz, H. Chun, L. Sharma, , J. Koff

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

bioRxiv · May 24, 2024Cell Biology

Bacterial Receptors but Not Anti-Phage Defense Mechanisms Determine Host Range for a Pair of Pseudomonas aeruginosa Lytic Phages

D. M. Mueller, J. Pourtois, K. M. Kim, B. Targ, E. Burgener, C. Milla, M. Hajfathalian, H. Selvakumar, J. Berry, M. Hopkins, R. McBride, J. Antani, P. E. Turner, J. Koff, P. Bollyky

The paper identifies bacterial receptor genes determining phage host range, showing defense mechanisms are not predictive of susceptibility.

bioRxiv · Apr 30, 2024 · PreprintMicrobiology

A 3D Printed Ventilated Perfused Lung Model Platform to Dissect the Lung's Response to Viral Infection in the Presence of Respiration

I. D. Derman, M. A. Alioglu, D. Banerjee, S. E. Holton, D. N. Klunk, M. Nagamine, S. H. A. Rizvi, C. Mikacenic, N. Celik, D. C. Castaneda, W. Prajakta, P. Chen, M. Schotsaert, M. E. Peeples, K. Palucka, , I. T. Ozbolat

This study develops a 3D printed lung model to investigate how ventilation affects viral infection and lung responses in vitro.

bioRxiv · Sep 24, 2023 · PreprintBioengineering

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

D. C. Castaneda, S. Jangra, M. Yurieva, J. Martinek, M. Callender, M. Coxe, A. Choi, J. G.-B. Diego, J. Lin, T.-C. Wu, F. Marches, D. Chaussabel, P. Yu, A. Salner, G. Aucello, , K. Palucka

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

bioRxiv · Mar 30, 2023Immunology