M. Ni

Combined aerobic and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adults

This study examines how combined aerobic and resistance exercise training affects the spatial transcriptome of skeletal muscle in young adults, identifying fiber type-specific gene expression changes and shifts in interstitial cell populations.

HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes

The paper shows IgA1 autoantibodies enhance pDC IFN responses when combined with IgG in RNA-containing immune complexes through FcR receptor interaction.

Electron transport inhibition increases cellular dependence on purine transport and salvage

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

Clathrin Light Chains are essential in negative regulation of cell death and immunity in Arabidopsis through interacting with autophagy pathway

This study shows that clathrin light chains in Arabidopsis interact with autophagy proteins, impairing autophagy and leading to accelerated senescence and immune activation.

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

Fluorescence complementation enables quantitative imaging of cell penetrating peptide-mediated protein delivery in plants including WUSCHEL transcription factor

The paper introduces DCIP, a tool for quantitatively measuring protein delivery in plants, demonstrating its use with cell-penetrating peptides and showing delivery of a transcription factor.

REGEN-COV protects against viral escape in preclinical and human studies

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

Molecular taxonomy of human ocular outflow tissues defined by single cell transcriptomics

This study uses single-cell RNA sequencing to create a cell atlas of human ocular outflow tissues, identifying 12 cell types and mapping glaucoma-related gene expression.

A novel polyphasic identification system for genus Trichoderma

This paper develops a polyphasic identification system for Trichoderma species using molecular and phenotypic data, improving identification accuracy and coverage.

Nanoscale fracture of defective popgraphene monolayer

This study investigates the fracture behavior of defective popgraphene using molecular dynamics and continuum modeling, revealing how different defect types affect fracture stress.