J. Nie

Stand-alone lipoylated H-protein of the glycine cleavage system enables glycine cleavage and the synthesis of glycine from one-carbon compounds in vitro

This paper shows that lipoylated H-protein can catalyze glycine cleavage and synthesis reactions in vitro without the other GCS proteins.

A non-structural pure enzyme protein forms an LCST type of stimuli-responsive and reversible hydrogel with novel structure and catalytic activity

This paper reports a unique enzyme, LplA, that forms a stimuli-responsive and reversible hydrogel with catalytic activity, revealing its structural and functional mechanisms.

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

Insulin Resistance Mediates Crosstalk between Skeletal Muscle and the Heart to Prevent Cardiac Dysfunction

This study shows that insulin resistance in skeletal muscle protects the heart from dysfunction in diet-induced obesity, despite worsening obesity and metabolic syndrome.

De Novo Lipid Labeling for Comprehensive Analysis of Subcellular Distribution and Trafficking in Live Cells

This paper develops a de novo lipid labeling method using a single fluorescent probe to analyze subcellular distribution and trafficking of major lipid species in live cells, revealing new biological functions of lipid metabolic enzymes.

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

Isolation and long-term expansion of a single adult human renal epithelial cell with efficient kidney regeneration capacity

This study isolates and expands SOX9+ renal epithelial cells from adult humans, showing their ability to regenerate kidney tissue in mice.

Visual impairment, spectacle wear and academic performance among junior high school students in western China

This study examines the relationship between visual impairment, spectacle use, and academic performance in junior high school students in western China, finding that spectacle ownership is linked to better test performance.

Fast, 3D isotropic imaging of whole mouse brain using multi-1 angle-resolved subvoxel SPIM

The paper was withdrawn due to inaccurate descriptions of other techniques in the manuscript.

Lossless and Contamination-Free Digital PCR

This paper introduces CLEAR-dPCR, a lossless and contamination-free digital PCR technology that improves accuracy and dynamic range compared to existing platforms.

Single-cell profiling of tumor-reactive CD4+ T-cells reveals unexpected transcriptomic diversity

The paper uses single-cell RNA sequencing to reveal diverse transcriptomic patterns in CD4+ T cells responding to tumors, highlighting differences from virus responses and potential implications for immunotherapy.

A mosaic of independent innovations involving eyes shut are critical for the evolutionary transition from closed to open rhabdoms

The paper identifies three molecular changes in EYS and its interactions that enabled the evolutionary transition from fused to open rhabdoms in insect eyes.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.