Author

D. Kappei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Biochemistry· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 4 Assay:proteomics· 4 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

F. Butter· 3 shared G. Rane· 3 shared V. Khanchandani· 3 shared F. Li· 2 shared N. Viceconte· 2 shared N. Zaal Anuar· 2 shared S. Wang· 2 shared V. L. S. Kuan· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCell Biology

F. Butter

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression

G. Rane, V. L. S. Kuan, S. Wang, M. M. H. Mok, V. Khanchandani, J. Hansen, I. Norvaisaite, W. K. Yong, A. Jahn, V. Mukundan, Y. Shi, M. Osato, F. Li, D. Kappei

This study identifies ZBTB48 as a transcription factor that regulates B-cell-specific CIITA expression by binding to its promoter and establishing open chromatin.

bioRxiv · Jul 25, 2023Immunology

An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing

Z. Li, B. Zhang, J. J. Chan, H. Tabatabaeian, Q. Y. Tong, X. H. Chew, X. Fan, P. Driguez, C. Chan, F. Cheong, S. Wang, B. E. Siew, I. J.-W. Tan, K. Y. Lee, B. Lieske, , Y. Tay

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

bioRxiv · Apr 21, 2023Cancer Biology

ChIP-MS reveals the local chromatin composition by label-free quantitative proteomics

W. K. Yong, G. Rane, N. Zaal Anuar, X. Shao, C. Y. Goh, V. Khanchandani, V. L. S. Kuan, M. Jeitany, P. Koeffler, L.-W. Deng, T. Sanda, D. Kappei

The paper introduces ChIP-MS, a method combining ChIP with label-free quantitative mass spectrometry to analyze local chromatin composition, demonstrating its application at telomeres, with transcription factors, in tissue, and via dCas9-driven enrichment.

bioRxiv · Jan 27, 2023Biochemistry

E4F1 and ZNF148 are transcriptional activators of the A57C and wildtype TERT promoter

B. H. Chua, L. Ferry, C. Domrane, N. Zaal Anuar, A. Wittek, S. Jha, F. Butter, D. G. Tenen, P.-A. Defossez, D. Kappei

The paper identifies E4F1 and ZNF148 as transcriptional activators of the A57C and wildtype TERT promoter, respectively, and shows their role in upregulating TERT transcription and telomerase activity.

bioRxiv · Jan 13, 2023Cancer Biology

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

H. Braun, Z. Xu, F. Chang, N. Viceconte, G. Rane, M. Levin, L. Lototska, F. Roth, A. Hillairet, A. Fradera-Sola, V. Khanchandani, O. Dreesen, Y. Yang, Y. Shi, F. Li, , D. Kappei

This study identifies ZNF524 as a telomere-binding protein that maintains telomere integrity by supporting TRF2/RAP1 localization and preventing DNA damage and recombination.

bioRxiv · Nov 30, 2022Cell Biology

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

U. S. Srinivas, G. K. Ramachandran, J. D. Wardyn, M. M. Hoppe, Y. Peng, S. Lim, M. Y. Lee, P. C. Peethala, O. An, A. Shendre, B. W. Q. Tan, T. S. C. Norbert, P. Jaynes, L. Hu, R. Jakhar, , A. D. Jeyasekharan

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

bioRxiv · Jun 1, 2021 · PreprintCancer Biology

The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1

S. Dietz, M. V. Almeida, E. Nischwitz, J. Schreier, N. Viceconte, A. Fradera Sola, C. Renz, A. Ceron-Noriega, H. D. Ulrich, D. Kappei, R. F. Ketting, F. Butter

This study identifies TEBP-1 and TEBP-2 as double-stranded telomere-binding proteins in C. elegans that form a complex with POT-1, and shows their distinct roles in telomere length regulation and fertility.

bioRxiv · Aug 19, 2020Cell Biology

Programmed DNA elimination of germline development genes in songbirds

C. M. Kinsella, F. J. Ruiz-Ruano, A.-M. Dion-Cote, A. J. Charles, T. I. Gossmann, J. Cabrero, D. Kappei, N. Hemmings, M. J. P. Simons, J. P. M. Camacho, W. Forstmeier, A. Suh

The paper identifies and characterizes the germline-restricted chromosome (GRC) in zebra finches, revealing its dynamic evolution and functional role in germline-soma genome differentiation.

bioRxiv · Dec 22, 2018Evolutionary Biology