D. Bhattacharya

Hot springs viruses at Yellowstone National Park have ancient origins and are adapted to their thermophilic hosts.

The paper analyzes viruses from geothermal springs in Yellowstone National Park, finding ancient origins and adaptations to thermophilic hosts in red algae-associated viral communities.

YlaN is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus

This study identifies YlaN as an Fe(II) binding protein in S. aureus that relieves Fur-mediated repression of gene expression during Fe deprivation.

Cholesterol-associated Locus EHBP1 Protects against NASH Fibrosis

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers

This study genetically modifies human pluripotent stem cells to evade immune rejection in mice by knocking out HLA genes and adding inhibitory factors, leading to persistent teratomas in immunocompetent models.

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

This study determines the structure of S. aureus GpsB's N-terminal domain, revealing its interaction with FtsZ and PBP4, and shows its essential role in cell division.

Lung spatial profiling reveals a T cell signature in COPD patients with fatal SARS-CoV-2 infection

The paper uses spatial transcriptomic and proteomic profiling to analyze lung tissues from COPD patients who died of COVID-19, revealing increased T-lymphocytes and altered immune responses.

Multiple waves of viral invasions in Symbiodiniaceae algal genomes

The paper identifies 59 candidate viral-derived horizontal gene transfers in 10 Symbiodiniaceae genomes, proposes a model for their origin and fate, and describes their taxonomic affiliation and genomic context.

Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

The paper shows that 2NBDG uptake in cells occurs independently of known glucose transporters, suggesting a separate mechanism for its import.

The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccination

This study shows older adults have robust cellular immunity and comparable neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination.

Tightly constrained genome reduction and relaxation of purifying selection during secondary plastid endosymbiosis

This study examines gene loss and selection changes in plastid genomes during secondary endosymbiosis in three lineages, finding constrained gene loss and temporary relaxation of purifying selection.

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor

The study analyzes SARS-CoV-2 isolates from India, finding a mutation in the RBD that increases binding affinity to human ACE2, suggesting potential for higher infectivity and cross-species transmission.

p107 mediated mitochondrial function controls muscle stem cell proliferative fates

This study identifies p107's role in regulating mitochondrial function to control muscle stem cell proliferation by modulating ATP production and interacting with Sirt1.

ZBTB38 is dispensable for hematopoiesis and antibody responses.

This study shows ZBTB38 is not essential for hematopoiesis or antibody responses, as its deletion in mice does not impair germinal center B cells or immunization outcomes.

Metabolome shift associated with thermal stress in coral holobionts

The paper uses metabolomics to identify heat stress-associated metabolites in corals, finding dipeptides that may serve as diagnostic markers for thermal stress.

Paulinella micropora KR01 holobiont genome assembly for studying primary plastid evolution

The paper presents a genome assembly of Paulinella micropora KR01 and its symbiotic bacteria to study primary plastid evolution and bacterial symbiosis.

The genomes of polyextremophilic Cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

The paper analyzes 10 Cyanidiales genomes and finds 1% of their genes are horizontally transferred from polyextremophilic prokaryotes, with implications for eukaryotic genome evolution.

Strain maps characterize the symmetry of convergence and extension patterns during Zebrafish gastrulation

The paper maps strain patterns during zebrafish gastrulation to understand convergence and extension movements, identifying symmetric and rotational strain features.

Kingdom-wide comparison reveals conserved diurnal gene expression in Archaeplastida

The paper compares diurnal gene expression across nine Archaeplastida species, finding conserved transcriptional programs despite evolutionary divergence and lifestyle differences.