Z. J. Gartner

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics

This study uses single-cell transcriptomics to identify immune dysregulation in JDM, revealing coordinated type I interferon activity and B cell abnormalities.

HybriSeq: Probe-based Device-free Single-cell RNA Profiling

HybriSeq enables sensitive single-cell RNA profiling by combining in situ hybridization, split-pool barcoding, and sequencing to detect transcripts without end bias.

Configurational entropy is an intrinsic driver of tissue structural heterogeneity

The paper uses human mammary organoids to show that configurational entropy drives tissue structural heterogeneity by linking structural parameters to molecular and microenvironmental factors.

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

This study analyzes single-cell transcriptomes of primary tumors and metastases from breast cancer models, identifying transcriptional differences and gene signatures linked to metastatic potential and patient outcomes.

Microenvironmental engineering improves the self-organization of patterned microvascular networks

This study shows that engineering the microenvironment with fibrillar matrices and removing a serum component improves the self-organization of patterned endothelial cells into perfusable microvascular networks.

Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

Size-dependent protein segregation creates a spatial switch for Notch signaling and function

The paper shows that spatial constraints at cadherin-based adherens junctions regulate Notch cleavage by gamma-secretase, affecting signaling and cell differentiation.

Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

This study shows lactoferrin reverses methotrexate-induced epithelial barrier defects by inhibiting TGF-β mediated epithelial-mesenchymal transition in intestinal models.

Linked optical and gene expression profiling of single cells at high throughput

This paper introduces a high-throughput platform that links optical and gene expression profiling of single cells, demonstrating accurate measurements from thousands of cells and characterizing DNA and RNA changes in Jurkat cells through the cell cycle.

Printed Droplet Microfluidics for on demand dispensing of picoliter droplets and cells

This paper introduces a technology for high-throughput dispensing of picoliter droplets and cells with deterministic control, enabling precise array generation and integration of multiple measurement modalities.

Tissue Folding by Mechanical Compaction of the Mesenchyme

This study shows mechanical compaction of mesenchyme drives tissue folding in vitro through ECM strain and collagen alignment, without genetic engineering.

A DNA-based T cell receptor reveals a role for receptor clustering in ligand discrimination

This study uses DNA-based T cell receptors to show that receptor clustering enhances ligand discrimination by enabling kinetic proofreading.