Y. Adachi

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

Two doses of mRNA vaccine elicit cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant

The paper shows that two doses of mRNA vaccine generate cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant, which are retained and contribute to enhanced antibody responses after a third dose.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

All-trans retinoic acid induces GADD34 gene expression via transcriptional regulation by Six1-TLE3 and post-transcriptional regulation by p38-TTP in skeletal muscle

This study shows ATRA increases GADD34 expression in muscle through transcriptional activation and post-transcriptional stabilization, altering myosin heavy chain types in myotubes.

Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models

This paper evaluates four commonly used murine models of atrial fibrillation and finds they do not exhibit authentic AF characteristics, such as micro-reentrant circuits or typical ECG features.

RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody Design

This paper introduces RosettaAntibodyDesign (RAbD), a computational framework for antibody design that improves affinity by redesigning CDRs using structural and sequence-based methods.