Author

S. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Physiology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

A. Bongiovanni· 1 shared A. C. Barbosa· 1 shared A. C. V. Krepischi· 1 shared A. Hatton· 1 shared A. Lelis Carvalho· 1 shared A. Major· 1 shared A. Nagano· 1 shared A. Nicosia· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCell Biology

A. Bongiovanni

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Beyond Kaftrio: mechanistic insights to maximize N1303K-CFTR rescue

I. Pranke, V. Capurro, B. Chevalier, E. Pesce, V. Tomati, C. Pastorino, A. Hatton, S. Urien, M. Lena, E. Dreano, R. Bocciardi, F. Zara, S. Pantano, V. Terlizzi, C. Lucanto, , S. Bui

This study investigates the mechanism of N1303K-CFTR rescue by ELX/TEZ and ETI combotherapy, showing increased protein amounts and activity with potential clinical benefits.

bioRxiv · Feb 29, 2024 · PreprintPhysiology

A culture-based approach to study ecological interactions among the microbial species of the human scalp.

S. Bhattacharya, T. Roth, S. Costa, A. Santoro, W. Mazza, K. Coyte, C. Clavaud, K. Foster, W. Kim

This study develops an in vitro model to examine ecological interactions among three scalp microbiota species, finding that S. epidermidis suppresses others, while C. acnes exploits M. restricta.

bioRxiv · Sep 7, 2023 · PreprintMicrobiology

Harnessing Nature's nanoSecrets: biocompatibility, biodistribution and bioactivity of extracellular vesicles derived from microalgae

G. Adamo, P. Santonicola, S. Picciotto, P. Gargano, A. Nicosia, V. Longo, N. Aloi, D. P. Romancino, A. Paterna, E. Rao, S. Raccosta, R. Noto, M. Salamone, I. Deidda, S. Costa, , A. Bongiovanni

This study evaluates the biocompatibility, biodistribution, and bioactivity of microalgae-derived extracellular vesicles in preclinical models.

bioRxiv · Apr 4, 2023 · PreprintCell Biology

In vivo genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

Y. Wei, S. Iyer, S. Costa, Z. Yang, M. Kramer, E. Adelman, O. Klingbeil, O. Demerdash, S. Polyanskaya, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. Figueroa, C. Vakoc

The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.

bioRxiv · Dec 22, 2020 · PreprintCancer Biology

Trpm8 modulates thermogenesis in a sex-dependent manner without influencing cold-induced bone loss

A. Lelis Carvalho, A. Treyball, D. J. Brooks, S. Costa, R. J. Neilson, M. R. Reagan, M. L. Bouxsein, k. Motyl

This study shows TRPM8 affects thermogenesis and bone density differently in males and females without impacting cold-induced bone loss.

bioRxiv · Mar 18, 2020 · PreprintPhysiology

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

R. Xu, W. Jones, E. Wilcz-Villega, S. Costa, V. Rajeeve, R. B. Bentham, K. Bryson, A. Nagano, B. Yaman, S. Olendo Barasa, Y. Wang, C. Chelala, P. Cutillas, G. Szabadkai, C. Frezza, K. Bianchi

This study shows that IKKε, a breast cancer oncogene, reprograms mitochondrial function and serine metabolism independently of its canonical signaling role, promoting cancer cell proliferation.

bioRxiv · Nov 26, 2019Cancer Biology

Mutational burden of hepatoblastomas: a role for the CX3CL1/CX3CR1 chemokine signaling pathway

T. Aguiar, M. Prates, S. Costa, T. Rodrigues, J. S. de Barros, A. C. Barbosa, M. Maschietto, R. Valieris, G. R. Fernandes, M. Cypriano, S. R. C. de Toledo, A. Major, I. Tojal, M. L. d. P. Apezzato, D. M. Carraro, , A. C. V. Krepischi

This study identifies CX3CL1/CX3CR1 pathway activation and a novel mutational signature in hepatoblastomas through exome sequencing and expression analysis.

bioRxiv · Feb 22, 2019 · PreprintCancer Biology