Author

M. Kramer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:chromatin & epigenetic regulation· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:ChIP-seq· 3 Assay:DNA methylation· 3

Frequent Co-Authors

W. R. McCombie· 4 shared B. Thomma· 3 shared D. Cook· 3 shared M. Seidl· 3 shared E. Hodges· 2 shared G. Lorencini Fiorin· 2 shared G. van den Berg· 2 shared K. Chang· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

W. R. McCombie

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication.

J. Cahn, M. Regulski, J. Lynn, E. Ernst, C. de Santis Alves, S. Ramakrishnan, K. Chougule, S. Wei, Z. Lu, X. Xu, J. Drenkow, M. Kramer, A. Seetharam, M. B. Hufford, W. R. McCombie, , R. A. Martienssen

The paper identifies bi-directionally expressed enhancers in maize with domestication signatures using integrated epigenomic and transcriptomic data from multiple tissues and inbred lines.

bioRxiv · Feb 22, 2024Plant Biology

Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen

D. Torres, M. Kramer, V. Tracanna, G. Lorencini Fiorin, D. Cook, M. F. Seidl, B. Thomma

This study examines the 3D chromatin organization in Verticillium dahliae and links it to evolutionary features in the Verticillium genus.

bioRxiv · Apr 4, 2023Microbiology

Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides

H. Saad, T. Majer, K. Bhattarai, S. Lampe, D. T. Nguyen, M. Kramer, J. Straetener, H. Broetz-Oesterhelt, D. A. Mitchell, H. Gross

The paper discovers and characterizes two novel biaryl-containing lasso peptides, revealing new structural modifications and biosynthetic enzymes.

bioRxiv · Mar 6, 2023 · PreprintBiochemistry

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells

P. Mistry, C. S. Boddupalli, G. Belinsky, J. Gans, E. Teeple, T.-H. Nguyen, S. Mehta, L. Guo, M. Kramer, J. Ruan, H. Wang, M. Davison, V. DJ, B. Zhang, K. Klinger, S. Nair

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

bioRxiv · May 13, 2022Immunology

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice

K. Xie, H. Fuchs, E. Scifo, D. Liu, A. Aziz, J. A. Aguilar- Pimentel, O. V. Amarie, L. Becker, P. da Silva-Buttkus, J. Calzada-Wack, Y.-L. Cho, Y. Deng, A. C. Edwards, L. Garrett, C. Georgopoulou, , Schmidt-Weber

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

bioRxiv · Mar 25, 2022Physiology

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

S. Bhatia, M. Kramer, S. Russo, P. Naik, G. Arun, K. Brophy, P. A. Andrews, C. Fan, C. M. Perou, J. Preall, T. Ha, D. Plenker, D. Tuveson, A. Rishi, J. E. Wilkinson, , D. L. Spector

This study develops and characterizes patient-derived TNBC organoids that recapitulate tumor properties and identify key signaling pathways involved in cancer progression.

bioRxiv · Aug 9, 2021Cancer Biology

Local rather than global H3K27me3 dynamics associates with differential gene expression in Verticillium dahliae

M. Kramer, M. Seidl, B. P. H. J. Thomma, D. Cook

The paper shows that H3K27me3 dynamics are not globally erased during differential gene expression in Verticillium dahliae, but rather local changes associate with some differentially expressed genes.

bioRxiv · May 4, 2021Microbiology

The H4K20 demethylase DPY-21 regulates thedynamics of condensin DC binding

L. Breimann, A. K. Morao, J. Kim, D. Jimenez, N. Maryn, K. Bikkasani, M. J. Carrozza, S. E. Albritton, M. Kramer, L. A. Street, K. Cerimi, V.-F. Schumann, E. Bahry, S. Preibisch, A. Woehler, S. Ercan

The paper shows DPY-21 regulates condensin DC binding dynamics in C. elegans, with a non-catalytic role in transcription repression.

bioRxiv · Apr 11, 2021Cell Biology

The interspecific fungal hybrid Verticillium longisporum displays sub-genome-specific gene expression

J. Depotter, F. van Beveren, L. Rodriguez-Moreno, M. Kramer, E. Chavarro Carrero, G. Lorencini Fiorin, G. van den Berg, T. Wood, B. Thomma, M. Seidl

This study examines the genomic and transcriptomic dynamics of the fungal hybrid Verticillium longisporum, revealing sub-genome-specific gene expression patterns and evolutionary adaptations.

bioRxiv · Feb 22, 2021 · PreprintMicrobiology

In vivo genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

Y. Wei, S. Iyer, S. Costa, Z. Yang, M. Kramer, E. Adelman, O. Klingbeil, O. Demerdash, S. Polyanskaya, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. Figueroa, C. Vakoc

The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.

bioRxiv · Dec 22, 2020 · PreprintCancer Biology

Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

Z. Yang, Y. Wei, X. S. Wu, S. V. Iyer, M. Jung, E. R. Adelman, O. Klingbeil, M. Kramer, O. E. Demerdash, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. E. Figueroa, A. Smogorzewska, C. R. Vakoc

This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.

bioRxiv · Oct 23, 2020Cancer Biology

DNA methylation in Verticillium dahliae requires only one of three putative DNA methyltransferases, yet is dispensable for growth, development and virulence

M. Kramer, D. Cook, G. van den Berg, M. Seidl, B. Thomma

This study identifies Dim2 as the primary DNA methyltransferase in Verticillium dahliae, showing that DNA methylation is dispensable for growth, development, and virulence.

bioRxiv · Aug 26, 2020Microbiology