D. Stolz

Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variant

This study creates a human iPSC-derived hepatocyte model with the TM6SF2 E167K mutation to study its effects on lipid metabolism and MASLD.

Engineering Rotating Apical-Out Airway Organoid for Assessing Respiratory Cilia Motility

This study develops a rotating apical-out airway organoid model and computational framework to assess cilia motility and its defects in disease states.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Metformin preconditioning protects against myocardial stunning and preserves mitochondrial dynamics and protein translation in a mouse model of cardiac arrest

This study shows metformin pretreatment protects against cardiac and renal damage after cardiac arrest in mice through AMPK activation, preserving protein translation and mitochondrial function.

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.