Author

W. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

L.-Q. Wang· 2 shared Y. Liang· 2 shared A. A. Salahudeen· 1 shared A. Batish· 1 shared C. E. Milla· 1 shared C. J. Kuo· 1 shared C. Liu· 1 shared C. M. Lee· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

L.-Q. Wang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

L.-Q. Wang, Y. Ma, M.-Y. Zhang, H.-Y. Yuan, X.-N. Li, K. Zhao, W. Xia, X. Huang, J. Chen, L. Zou, D. Li, Z. Wang, W. Le, C. Liu, Y. Liang

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Science Advances · Nov 1, 2024Peer-reviewedBiochemistry

Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS

J.-Q. Liu, H. Liu, Y. Li, X. Liu, L.-Q. Wang, K. Wang, Z. Yang, Q. Fu, X. Xu, J. Chen, Y. Zhang, J. Zhou, W. Le, M. Cui, Y. Liang

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

bioRxiv · Mar 16, 2024Biochemistry

Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia

S. Vaidyanathan, A. A. Salahudeen, Z. M. Sellers, D. T. Bravo, S. S. Choi, A. Batish, W. Le, S. De La O, M. P. Kaushik, N. Galper, C. M. Lee, G. Bao, E. H. Chang, J. J. Wine, C. E. Milla, , M. H. Porteus

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.

bioRxiv · Feb 26, 2019 · PreprintBioengineering