Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
E. H. Ervin, D. Ahern, F. Liu, A. Rendek, Z. Soonawalla, U. Oppermann, P. Hulley, S. Pauklin
The paper uses mass cytometry to analyze stemness states in PDAC, revealing molecular heterogeneity and identifying a subset with plastic phenotypes.
bioRxiv · Feb 27, 2024 · PreprintCancer Biology
Y. Feng, L. Cai, M. Pook, F. Liu, C.-H. Chang, M. A. Mouti, R. Nibhani, S. Wu, S. Deng, S. Militi, J. Dunford, M. Philpott, Y. Fan, G.-C. Fan, Q. Liu, , S. Pauklin
This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.
bioRxiv · Mar 2, 2023Cancer Biology
A. Dickson, E. Yutuc, C. A. Thornton, J. E. Dunford, U. Oppermann, Y. Wang, W. J. Griffiths
The paper identifies HSD3B1 as an enzyme in human placenta that converts oxysterols into 3-oxo-4-ene derivatives, which are found in umbilical cord and maternal plasma.
bioRxiv · Apr 1, 2022Biochemistry
A. Kayabolen, E. Yilmaz, G. N. Sahin, F. Seker-Polat, A. Cingoz, B. Isik, S. Acar, S. Karahuseyinoglu, H. Wakimoto, D. P. Cahill, I. Solaroglu, A. P. Cribbs, U. Oppermann, T. Bagci-Onder
This study identifies GSK-J4 and Belinostat as effective therapies for IDH1-mutant glioma by targeting KDM6A/B and HDACs, showing synergistic effects in vitro and in vivo.
bioRxiv · Nov 26, 2020 · PreprintCancer Biology
J. A. Heward, L. Koniali, A. D'Avola, K. Close, A. Yeomans, M. Philpott, J. Dunford, T. Rahim, A. F. Al Seraihi, J. Wang, K. Korfi, S. Araf, S. Iqbal, F. Bewicke-Copley, E. Kumar, , J. Fitzgibbon
This study shows that inhibiting KDM5 demethylases restores H3K4 methylation and reactivates genes in KMT2D mutant lymphomas, offering a potential therapeutic strategy.
bioRxiv · Jun 30, 2020Cancer Biology
A. P. Cribbs, S. Terlecki-Zaniewicz, M. Philpott, J. Baardman, D. Ahern, M. Lindow, S. Obad, H. Oerum, B. Sampey, P. Mander, H. Penn, P. Wordsworth, P. Bowness, R. K. Prinjha, M. de Winther, , U. Oppermann
This study identifies KDM6A and KDM6B as regulators of human Th17 cell development and effector functions by affecting metabolism and cytokine production.
bioRxiv · Oct 30, 2019Immunology