C.-H. Chang

IL-3-driven T cell-basophil crosstalk enhances anti-tumor immunity

This study shows that IL-3 enhances anti-tumor immunity by promoting CTL-basophil interactions, improving CTL activity and tumor suppression.

Prevalent fast evolution of genes involved in heterochromatin functions

The paper investigates the evolutionary dynamics of genes involved in heterochromatin functions in Drosophila, finding they evolve faster than Polycomb-based repressive chromatin genes.

Diversification and recurrent adaptation of the synaptonemal complex in Drosophila

This study examines the evolutionary dynamics of the synaptonemal complex in Drosophila, revealing recurrent positive selection and diversification of SC genes through duplications and regulatory changes.

Turnover of retroelements and satellite DNA drives centromere reorganizationover short evolutionary timescales in Drosophila

The paper investigates centromere reorganization in Drosophila species, finding rapid turnover of retroelements and satellite DNA over short evolutionary timescales.

Reprogramming human B cells with custom heavy chain antibodies

This paper describes a genome editing strategy to reprogram human B cells to express custom heavy chain antibodies that respond to immunization.

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

Protein N-Terminomics Reveals Major Proteases in Regulating Beige Adipocyte Differentiation

This study identifies proteases regulating beige adipocyte differentiation through N-terminomics and functional experiments.

Genetic conflicts between sex chromosomes drive expansion and loss of sperm nuclear basic protein genes in Drosophila

This study investigates SNBP gene evolution in Drosophila, finding that genetic conflicts between sex chromosomes drive their expansion and loss.

EZH2/ hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

This study identifies the EZH2/SULF1/cMET axis as a driver of chondrosarcoma progression and shows that targeting this pathway can slow tumor growth and improve survival in mouse models.

Augmented glucose dependency of autoreactive B cells provides a treatment target forlupus

This study identifies glycolysis-dependent autoreactive B cells as key mediators of lupus and shows that targeting them with 2DG or BCMA-specific CAR T-cells improves disease outcomes.

The 24-chain core-shell nanostructure of wood cellulose microfibrils in seed plants

The paper resolves controversies about wood cellulose microfibril (CMF) nanostructure by showing most CMFs contain 24 chains, remain segregated, and do not fuse, overturning the 18-chain fusion hypothesis.

Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic load

The paper investigates the evolution of a meiotic drive system in Drosophila melanogaster, revealing epistatic selection and genomic consequences of the SD-Mal supergene.

Glutamine metabolism enables NKT cell homeostasis and function through the AMPK-mTORC1 signaling axis

Acoustic frequency-dependent physical mechanism of sub-MHz ultrasound neurostimulation

This study investigates how different acoustic frequencies affect ultrasound neuromodulation by examining cavitation and radiation forces in cultured rat cortical cells.

Effect of Phosphorylation on the Collision Cross Sections of Peptide Ions in Ion Mobility Spectrometry

This study systematically characterizes how phosphorylation affects collision cross sections of peptides in ion mobility spectrometry, finding that phosphorylation can reduce CCS despite increasing mass.

Isolation of protein N-terminal peptides by charge-mediated position- elective enrichment using strong cation exchange chromatography

The paper introduces a method to enrich and profile protein N-terminal peptides using TrypN digestion and CHAMP-SCX chromatography, achieving high specificity and sensitivity in human cell lysates.

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis

The paper tracks HIV-1 proviral clones over time in polyclonal populations, revealing stable, clone-specific expression patterns and clonal expansion dynamics independent of cell-type or metabolic factors.

Understanding patterns of abiotic and biotic stress resilience to unleash the potential of crop wild relatives for climate-smart legume breeding

This paper identifies patterns of abiotic and biotic stress resilience in Vigna species to guide conservation and breeding for climate-smart legumes.

Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger

This study shows that reactive oxygen species (ROS) regulate NKT cell inflammatory functions via PLZF, with ROS levels differing between NKT and other T cell subsets.