This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.

DOI 10.1038/s41590-020-0669-6

humanmouse

𝕏 PostBluesky

Cancer BiologybioRxivJan 19, 2018

5-hydroxy-4′-nitro-7-propionyloxy-genistein inhibited invasion and metastasis via inactivating wnt/β-catenin signal pathway in human endometrial carcinoma JEC cells

J. Bai, B. Yang, X. Luo

This study investigates the anticancer effects of HNPG on JEC cells, finding it inhibits proliferation, invasion, and metastasis by inactivating the Wnt/β-catenin pathway.

DOI 10.12659/msm.909472

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivJun 13, 2017

The polyploid state plays a tumor suppressive role in the liver

S. Zhang, K. Zhou, X. Luo…·H. Zhu

This study shows that polyploidy in the liver suppresses tumorigenesis while hyperdiploidy accelerates it in mutagen and high fat models.

DOI 10.1016/j.devcel.2018.01.010

mouseexperimental assay

𝕏 PostBluesky