X. Luo

This study shows that blebbistatin improves iPSC-CM quality during automated patch-clamp procedures, enabling reliable electrophysiological recordings and phenotyping of cardiac channelopathies.

This paper identifies new regulators of sRNA signaling in E. coli using a fluorescence-based genetic screen, revealing both general and RyhB-specific mechanisms.

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

This study develops a method to sequence nearly full-length rRNA genes from environmental samples, achieving high accuracy and coverage in microbial community analysis.

This study shows that CCL2 chemokine promotes early HIV reservoir formation by recruiting CCR2/5+ CD4 T cells to sites of inflammation during acute infection.

This study shows that bone marrow-derived AXL tyrosine kinase promotes cardiac allograft vasculopathy by enhancing immune cell accumulation and vascular smooth muscle cell proliferation.

The paper examines how elevated CO2 and nitrogen addition influence foliar phosphorus fractions in invasive and native species under varying phosphorus supplies.

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

This paper introduces a precision-targeted metabolomics method capable of analyzing diverse biological matrices and identifies differential metabolomes in rats with CCl4-induced hepatitis.

The paper identifies a core bacterial consortium that collaborates with OsHV-1 Var in POMS pathogenesis, showing metabolic complementarity and conservation across environments.

This paper describes a strategy to achieve brain-restricted mTOR inhibition using a combination of a brain-permeable inhibitor and a brain-impermeable ligand, while preserving systemic mTOR activity.

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

The paper introduces implantable photonic neural probes that enable light-sheet fluorescence imaging in brain tissues without additional micro-optic components.

This study shows autophagy compensates for Lkb1 loss in adult mice, improving survival and mitigating metabolic and intestinal defects.

The paper integrates multiple regulatory data types in Arabidopsis to build an iGRN that predicts gene regulatory interactions and identifies novel ROS signaling regulators.

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study characterizes an obese ZSF1 rat model of cardiometabolic syndrome and shows that GDF15 treatment reduces metabolic markers and improves cardiac function.

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

The paper identifies and validates five plasma metabolite biomarkers for precise pancreatic cancer diagnosis and progression monitoring using metabolomics.

This study identifies five functional metabolites regulated by iron via siderophore-dependent pathways that directly influence biofilm formation.

This study shows anacardic acid reduces PE-induced cardiac hypertrophy by inhibiting JNK signaling and HAT-mediated histone acetylation in mice.

This study examines seasonal changes in soil microbial diversity and its relationship with soil chemical properties in a subtropical orchard.

The paper evaluates if workshops increase invasive species reports to EDDMapS in the Mid-Atlantic US using a General Linear Model across 2012-2017.

The paper identifies surfactin, a cyclic lipopeptide from bacterial peptidoglycan, as a broad-spectrum virucidal compound that disrupts enveloped virus infectivity.

This paper develops a method to monitor anesthesia depth using EEG features from sample entropy and autoregressive models, achieving high correlation with BIS index.

The paper shows that leukocytes use a bistable mechanism involving integrins LFA-1 and VLA-4 to decide their direction in response to flow.