Y.-C. Chiang

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins

This paper presents crystal structures of four plant AAAD paralogs, revealing structural features and mutations that underlie divergent substrate selectivity and convergent aldehyde synthase activity evolution.

Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein

This paper introduces a sonogenetic method using an engineered auditory-sensing protein to control cellular activities with ultrasound, showing it can stimulate neurons in deep brain regions non-invasively.

Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants

This study identifies structural and functional differences in chalcone synthase (CHS) catalytic cysteine reactivity across land plant lineages, showing increased nucleophilicity in euphyllophytes compared to basal plants.

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

The paper develops a method to rapidly deplete tubulin glutamylation in primary cilia, revealing its role in intraflagellar transport and Hedgehog signaling without affecting other PTMs.