D. Deng

Unravelling an Efficient O2/Reductant-Dependent Catalytic Route in Heme Peroxygenases for Sustainable Applications

This paper identifies an O2/reductant-dependent catalytic pathway in heme peroxygenases that avoids H2O2-induced inactivation, enabling efficient and sustainable chemical transformations.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Isolation and electrochemical analysis of a facultative anaerobic electrogenic strain Klebsiella sp. SQ-1

The paper isolates a facultative anaerobic electrogenic strain Klebsiella sp. SQ-1 and demonstrates its high current density and power density in microbial fuel cells.

Oncogenic context shapes the fitness landscape of tumor suppression

The paper models tumor suppression fitness landscapes across four oncogenic contexts and finds context-specific tumor suppressor effects.

Quantitative Profiling of Lysosomal pH Heterogeneity using Fluorescence Lifetime Imaging Microscopy

This paper introduces a FLIM-based method to quantitatively analyze lysosomal pH heterogeneity in mammalian cells and C. elegans, revealing pH differences and dynamics without transgenic reporters.

Development of a PNGase Rc column for online deglycosylation of complex glycoproteins during HDX-MS

The paper develops a PNGase Rc column for online deglycosylation during HDX-MS, enabling efficient analysis of glycoproteins and mapping of mAb binding epitopes.

Effects of antennal segments defects on blood-sucking behavior in Aedes albopictus

This study investigates how defects in specific antennal segments of Aedes albopictus affect blood-feeding behavior by analyzing the role of flagellomeres in host detection.

Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis

This study shows that Listeria monocytogenes uses cellular respiration for NAD+ regeneration, which is critical for its pathogenesis and survival in host cells.

A ROS-Ca2+ signalling pathway identified from a chemical screen for modifiers of sugar-activated circadian gene expression.

The paper identifies a ROS-Ca2+ signalling pathway through a chemical screen that modifies sugar-activated circadian gene expression in plants.

The genomic context for aflatoxin B1-degrading Pseudomonas strains

The paper sequences and annotates three Pseudomonas strains, finding that AFB1-degrading strains have more genes related to xenobiotic metabolism and oxidoreductase activity.

Cryo-EM structures of human TMEM120A and TMEM120B

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

ActuAtor, a molecular tool for generating force in living cells: Controlled deformation of intracellular structures

The paper introduces ActuAtor, a molecular tool that generates intracellular force by inducing actin polymerization, leading to deformation of various subcellular structures.

Chidamide decreases c-MET mRNA methylation and in turn increases the sensitivity of non-small cell lung cancer to crizotinib

This study shows chidamide reduces c-MET mRNA methylation, increasing NSCLC sensitivity to crizotinib, particularly in cells with high c-MET expression.

P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib

This study shows that P16 methylation increases cancer cell sensitivity to palbociclib, a CDK4/6 inhibitor, through experimental and pharmacogenomic analyses.

Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau

The paper evaluates sand dune restoration methods on the Zoige Plateau, finding that sandbag and wicker with seeding improved soil conditions more than seeding alone.

Effects of P16 DNA Methylation on Proliferation, Senescence, and Lifespan of Human Fibroblasts

This study shows that P16 DNA methylation prevents senescence, promotes proliferation, and extends lifespan in human fibroblasts, potentially contributing to cancer development.