T. Inoue

Decoding host-microbiome interactions through co-expression network analysis within the non-human primate intestine

This study identifies gene modules from host-microbiome co-expression networks in marmoset intestines, revealing spatially varying interactions and new bacterial genes mediating host-microbiome relationships.

A fatal case of peritonitis caused by Dysgonomonas capnocytophagoides harboring the novel metallo-beta-lactamase gene blaDYB-1

The paper reports a fatal peritonitis case caused by Dysgonomonas capnocytophagoides carrying a novel metallo-beta-lactamase gene and an ermFS gene associated with multidrug resistance.

Multiple stressors and recruitment failure of long-lived endangered freshwater mussels with a complex life cycle

This study investigates how multiple stressors affect recruitment efficiency in endangered freshwater mussels, identifying parasitic and post-parasitic juvenile stages as critical bottlenecks.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85beta/AP-2-mediated endocytosis

The paper identifies a non-catalytic role of PI3K in cell migration via p85beta/AP-2-mediated endocytosis, independent of its catalytic activity.

Development of a new 3D tracking system for multiple marmosets under free-moving conditions

This paper develops a 3D tracking system for multiple marmosets to analyze long-term social interactions and behavioral changes.

The Transcription Factor Bach2 Negatively Regulates Natural Killer Cell Maturation and Function

This study shows Bach2 negatively regulates NK cell maturation and function by correlating with TCF1 and opposing effector molecule and cell cycle gene expression.

Multiple Ciliary Localization Signals Control INPP5E Ciliary Targeting

This study identifies four ciliary localization signals in INPP5E that regulate its ciliary targeting and reveals their functional interactions and implications for ciliopathies.

Development of a metatranscriptomic analysis method for multiple intestinal sites and its application to the common marmoset intestine

The paper develops a metatranscriptomic analysis method integrating metagenome and metatranscriptome to study functional changes in the microbiome across intestinal sites in common marmosets, revealing dynamic gene expression patterns.

Defunctionalizing Intracellular Organelles with Genetically-Encoded Molecular Tools Based on Engineered Phospholipase A/Acyltransferases (PLAATs)

The paper introduces PLAATs, engineered phospholipase A/acyltransferases, to rapidly defunctionalize organelles by remodeling membrane phospholipids, demonstrating effectiveness in mitochondria and peroxisomes.

Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

This study introduces humanized Vmat1 mutations into mice to investigate their impact on anxiety-related behaviors and amygdala function, finding reduced anxiety and altered neurophysiological activity.

Identification, crystallization and epitope determination of public TCR shared and expanded in COVID-19 patients

The paper identifies and crystallizes public TCRs from SARS-CoV-2-specific Tfh cells in COVID-19 patients, showing they recognize conserved spike epitopes and cross-react with symbiotic bacteria.

Synthetic design of farnesyl-electrostatic peptides for development of a protein kinase A membrane translocation switch

The paper designs a synthetic peptide switch that translocates between membranes in response to PKA activation, enabling visualization and manipulation of signal transduction pathways.

Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes

The paper investigates the relationship between serum bilirubin, urinary biopyrrin, and retinopathy severity in diabetic patients, finding that proliferative diabetic retinopathy is negatively associated with bilirubin levels.

Photocatalyst under visible light irradiation inactivates SARS-CoV-2 on an abiotic surface

This study shows that a visible light-responsive photocatalyst inactivates SARS-CoV-2 on surfaces under specific conditions, reducing viral titers and spike protein levels.

A phospho-regulated ensemble signal motif of α-TAT1 drives dynamic microtubule acetylation

This study identifies a phospho-regulated signal motif in -TAT1 that controls its subcellular localization and microtubule acetylation efficiency.

Lysosomal microautophagic pathway links proteostasis to protein aggregation disease

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

Activation of SnRK2 by the Raf-like kinase ARK represents a common mechanism of ABA response in embryophytes

The paper identifies Ser1029 phosphorylation as critical for ARK activation in ABA response, showing its role in SnRK2 regulation and stress tolerance in moss.

ActuAtor, a molecular tool for generating force in living cells: Controlled deformation of intracellular structures

The paper introduces ActuAtor, a molecular tool that generates intracellular force by inducing actin polymerization, leading to deformation of various subcellular structures.

Rational Design of a Protein Kinase A Nuclear-cytosol Translocation Reporter

The paper designs a single-fluorophore PKA reporter that matches the performance of FRET-based reporters and demonstrates its use in monitoring PKA activity in cells.

Rational design and implementation of a chemically inducible hetero-trimerization system

This paper designs a chemically inducible trimerization system by splitting FRB and FKBP, enabling precise control of tri-organellar junctions and membrane lipid perturbations in live cells.

Phytolacca americana PaGT2 is an ambidextrous polyphenol glucosyltransferase

This study identifies PaGT2 as an ambidextrous polyphenol glucosyltransferase capable of catalyzing glucosylation of stilbenoids and flavonoids using two independent catalytic residues.

RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis

This study shows RAMP1 in Kupffer cells is critical for immune-mediated hepatitis, as RAMP1-deficient mice showed severe liver injury and poor survival.

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

The paper develops a method to rapidly deplete tubulin glutamylation in primary cilia, revealing its role in intraflagellar transport and Hedgehog signaling without affecting other PTMs.