R. Ren

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

This study determines the cryo-EM structure of the EROS-NOX2-p22phox complex, revealing how EROS binds to NOX2 and regulates its activation.

Grand Biological Universe: Genome space geometry unravels looking for a single metric is likely to be futile in evolution

This study explores genome space geometry across seven kingdoms, showing that a single metric cannot accurately measure differences between biological universes due to space-time distortion.

Single-cell mutation rate of turnip crinkle virus (-)-strand replication intermediates

This study estimates the mutation rate of turnip crinkle virus (-)-strand replication intermediates in single cells and supports the BIAS replication model.

The structural basis of itch receptor MRGPRX1 activation

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

A small DNA virus initiates replication with no more than three genome copies per cell

This study shows DNA viruses like TYLCV undergo intracellular population bottlenecks, limiting replication to no more than three genome copies per cell, ensuring lethal mutations are purged.

Structural Insights into Sphingosine-1-phosphate Receptor Activation

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy

This paper develops FLT4-targeted nanocarriers for glaucoma therapy, showing improved IOP reduction and targeted delivery to Schlemms canal cells.

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

Single-molecule nanopore sensing of actin dynamics and drug binding

This study uses nanopore sensing to analyze actin dynamics and drug binding in native, unmodified actin molecules, revealing transitional states and binding stoichiometries.