Discover, rate, and discuss biology preprints.

The paper develops a model to classify invasive ductal carcinoma on whole slide images using transfer learning and weakly-supervised learning, achieving ROC AUCs of 0.95-0.98 on test sets.

The paper classifies decidual vasculopathy into types, finding atherosis of trophoblast type is distinct and linked to lower placental weight but not specific clinical features.

A progressive context encoder trained only on normal skin whole slide images flags melanoma regions without manual tumor labels, reaching 89% pixel-level accuracy across 9 test slides.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

This study shows that Nintedanib prevents cardiac fibrosis and dysfunction in a mouse model of heart failure, even after treatment interruption.

This study examines 2D and 3D vascular and white matter changes in CADASIL, HTRA1-AD, and sSVD using light-sheet fluorescence microscopy, revealing distinct patterns of degeneration.

This study identifies multiple triggering factors for mutation repair in RNA viruses and shows that cell-to-cell movement enhances mutation repair, opposing the Muller ratchet effect.

This study investigates lipid metabolism changes in soybean cultivars resistant and susceptible to Phytophthora sojae, identifying lipid biomarkers that may aid in developing plant protection strategies.

This study uses a microRNA-based droplet digital PCR assay to identify the tissue-of-origin and predict prognosis in cancers of unknown primary (CUPs).

This study shows that B6.Sst1S mice develop more severe pulmonary M. avium infection with increased type 2 macrophage activation and reduced T cell density compared to wild-type mice.

This study shows that expressing SARS-CoV-2 Spike S1 subunit in cardiomyocytes causes cardiac hypertrophy and inflammation via TLR4 activation, independent of ACE2.

The study examines APOL1 expression in the kidney using transgenic mice and finds it is not expressed in proximal tubules or filtered by them.

This study shows that inhibiting EPAC1 protects the heart from doxorubicin-induced toxicity without affecting its cancer-killing effects.

This study shows that SARS-CoV-2 envelope protein disrupts cellular homeostasis by forming ion channels, leading to altered Ca2+ and pH levels and membrane depolarization.

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

This study shows that PIK3CA mutations drive hepatocarcinogenesis independently of RASSF1A status, with early Galectin-1 upregulation and synergistic therapeutic effects of PIK3CA and Galectin-1 inhibitors.

This paper develops a deep learning method to segment and quantify podocyte foot process morphology in kidney tissue, confirming morphological changes in disease states.

This study identifies Stx2-induced differential gene expression and circadian rhythm disruption in proximal tubules, linking these changes to renal dysfunction.