Discover, rate, and discuss biology preprints.

This paper designs and evaluates a multiplex RT-PCR assay for SARS-CoV-2 detection, showing comparable performance to the modified CDC assay with higher efficiency and lower reagent use.

This study compares the effects of HSP25 vaccination and estrogen therapy on atherogenesis in post-menopausal mice, finding that both reduce plaque but through different mechanisms involving PCSK9 and LDLR.

This study shows that SS31 peptide prevents learning impairment and restores mitochondrial function in aged mice after short-term sleep deprivation.

This study shows BMPER deficiency leads to insulin resistance and hyperglycemia, and BMPER therapy improves these conditions in mice.

This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.

This study uses scanning acoustic microscopy to analyze structural and mechanical changes in aging renal arteries, finding that the tunica intima compensates for reduced stiffness in the tunica media.

This paper shows that inhibiting ferrochelatase (FECH) reduces retinal neovascularization and promotes physiological angiogenesis in a mouse model, suggesting FECH inhibitors could treat retinal diseases.

This study quantifies the NAD+ metabolome in human liver samples from patients with alcohol-related liver disease and finds reduced NAD+ and precursor levels associated with disease activity.

The paper shows that HSP27 immune complexes reduce inflammation and cholesterol uptake by modulating TLR4 and scavenger receptors in macrophages.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study uses 3D imaging to reveal the complex morphology of human endometrial glands and their pathological features in adenomyosis.

This study validates and compares three SARS-CoV-2 antibody assays, finding high sensitivity and specificity with low cross-reactions and interferences.

This study investigates the effect of sodium thiocyanate (SCN-) supplementation in a DSS-induced colitis model, finding it modulates MPO activity towards HOSCN but does not prevent colitis development.

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

This study shows canagliflozin extends lifespan in male but not female mice, likely by reducing peak glucose levels, similar to acarbose.

This study analyzes transcriptomic data from SIV-infected macaques to identify altered metabolic pathways and PARPs as potential therapeutic targets in HIV-associated neurodegeneration.

This study identifies 2,119 proteins and 2,950 phosphosites in sepsis-induced kidney injury, revealing pathways related to metabolism, oxidative stress, and energy consumption during transition to chronic kidney disease.

This paper introduces FF-OCT for rapid, automated diagnosis of GCA by analyzing structural changes in temporal artery biopsies.

The paper shows that HSP27 immune complexes increase LDLR expression, lowering plasma cholesterol and atherogenesis in ApoE-/- mice.

The paper develops a multiparametric scoring algorithm to assess the severity of missense mutations in the VHL protein using 285 ClinVar mutations, linking higher scores to pathogenicity.