C. S. Chen

Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces

This paper develops a 3D computational model of microvascular beds and interstitial spaces to better understand fluid flow dynamics and the effects of vascular permeability.

Perivascular cells function as mechano-structural sensors of vascular capillaries

This study shows perivascular cells sense mechanical changes in collagen matrix, affecting vascular function and contributing to fibrotic conditions.

Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues

This study investigates how matrix stiffness and alignment affect the structure and contractility of engineered myocardial tissues made from iPSC-derived cardiomyocytes.

Hyaluronic acid turnover controls the severity of Cerebral Cavernous Malformations in bioengineered human micro-vessels

This study shows that HA turnover in ECM affects CCM severity in 3D microfluidic models, independent of KLF2/4.

Dopamine and norepinephrine differentially mediate the exploration-exploitation tradeoff

This study investigates how dopamine and norepinephrine differentially influence exploration-exploitation tradeoff in mice using pharmacological manipulations and behavioral tasks.

Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise

This study shows that anchoring effects in mice during delay and probability discounting tasks are more likely due to decision noise than persistent value changes, with females showing less anchoring than males.

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds

This study shows that 3D scaffolds and mitogen stimulation promote cholangiocyte branching in a Notch-dependent manner, offering a model for studying biliary development.

Sex differences in learning from exploration

This study identifies sex differences in exploration patterns during value-based decision making in mice, showing males explore more but get stuck, while females explore less but learn faster.

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization

Optogenetic currents in myofibroblasts acutely alter electrophysiology and conduction of co-cultured cardiomyocytes

This study shows that optogenetic activation of myofibroblasts in co-cultures with cardiomyocytes reduces conduction velocity and shortens action potential duration, indicating electrical coupling between cell types.

Divergent strategies for learning in males and females

The paper finds that female and male mice use different strategies to learn value-based decisions in a two-armed bandit task, with females learning faster and using a more constrained approach.

Assembly properties of FtsZ from cyanobacterium Synechocystis sp. PCC 6803

This study examines the assembly properties of SyFtsZ from Synechocystis sp. PCC 6803, identifying different protofilament structures formed in GTP and GDP conditions.

A Bile Duct-on-a-Chip with Organ-Level Functions

This paper develops a bile duct-on-a-chip that mimics bile duct structure and barrier function, enabling studies of cholangiocyte permeability and toxin effects.