A. Sanchez

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.

This study evaluates the osteogenic potential of highly loaded nanohydroxyapatite scaffolds fabricated via melt extrusion additive manufacturing, showing enhanced mechanical properties and potential for in vitro and in vivo osteoinduction.

This study shows obesity modifies lung stromal cells to create pre-metastatic niches that enhance myeloid cell recruitment and breast cancer metastasis.

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

The paper investigates how nutrient interactions influence microbial community composition and finds that nutrient dominance patterns can predict community assembly in mixed nutrient environments.

This study develops a modeling framework to explore directed evolution strategies for engineering complex microbial communities, identifying effective methods to enhance their stability and functionality.

CellCountCV is a web-application using fully-convolutional neural networks for accurate cell counting and batch processing of microscopy images, achieving <4% error compared to expert estimates.

This study develops 3D scaffolds with antibiotic-loaded inorganic fillers for bone infection prevention and tissue regeneration, showing sustained antibiotic release and compatibility with cell differentiation.

The paper uses artificial selection experiments to compare propagule strategies in microbial communities, finding that selected communities achieve higher function than controls in two different experimental setups.

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

This study shows microbial community assembly is predictable from metabolic principles, with taxonomic variability explained by competitive exclusion within functional groups.

The paper uses DOA to analyze in vitro microbial communities, finding a negative correlation between dissimilarity and overlap in replicate habitats, suggesting potential for universal dynamics but not absolute universality.

This paper identifies the molecular mechanism by which the MLH1-MLH3 nuclease is activated in meiosis, showing its interaction with MutSγ, EXO1, RFC, and PCNA to process recombination intermediates.

This study shows that BMI1 and RNF2 suppress transcription-replication conflicts and CFS instability by regulating RNA Pol II elongation and fork protection.

This study shows that available energy fluxes drive a transition in microbial community diversity, stability, and function, shifting from resource-limited to preference-driven regimes.

This study evaluates long-amplicon PCR-based approaches using Nanopore sequencing for microbiota profiling at genus and species levels, finding that the rrn operon provides higher resolution than full-length 16S rRNA.

This study examines changes in biochemical composition during gonadal maturation in Octopus mimus and its effects on embryo and hatchling characteristics, including energy use and antioxidant defenses.

The paper shows that high-order interactions dominate the amylolytic function of microbial consortia, making community function unpredictable as size increases.

This study examines how metabolic mutations deform the fitness landscape of E. coli, showing short-range limited effects but long-term legacy impacts on evolutionary trajectories.

The paper shows that microbial communities re-assemble into predictable, stable communities through non-specific metabolic cross-feeding, even when grown in minimal environments.

This paper shows that in fission yeast lacking PNKP, lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks through alternative pathways.