Author

B. Martinac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Bioengineering· 2 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell signaling & trafficking· 6 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Organism:E. coli· 2 Assay:electrophysiology· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

C. D. Cox· 5 shared C. Cox· 3 shared g. Silvani· 2 shared M. Yao· 2 shared V. Romanov· 2 shared A. Buyan· 1 shared A. Chan· 1 shared A. D. Bershadsky· 1 shared

Activity by Year

2019-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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5 shared papersBioengineering

C. D. Cox

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels

C. Cox, Y. Zhang, Z. Zhou, T. Walz, B. Martinac

This study shows cyclodextrins activate mechanosensitive channels by mimicking membrane tension through lipid removal, revealing a universal mechanism for channel activation.

bioRxiv · Mar 8, 2021Biophysics

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

Y. Guo, J. Yu, Y. Wu, H. Gong, S. Kesteven, S. E. Iismaa, A. Chan, S. Holman, S. Pinto, A. Pironet, C. Cox, R. Vennekens, R. M. Graham, M. P. Feneley, B. Martinac

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

bioRxiv · Dec 21, 2020Physiology

Mechanosensitive calcium signaling in filopodia

A. K. Efremov, M. Yao, M. P. Sheetz, A. D. Bershadsky, B. Martinac, J. Yan

This study shows that stretching forces trigger Ca2+ influx through L-type channels in filopodia, causing persistent Ca2+ oscillations that influence cell migration.

bioRxiv · Oct 21, 2020Cell Biology

Biomechanical characterization of endothelial cells exposed to shear stress using acoustic force spectroscopy

g. Silvani, V. Romanov, C. D. Cox, B. Martinac

This study uses acoustic force spectroscopy to measure mechanical properties of endothelial cells under shear stress, showing force-dependent stiffness and contractile prestress changes.

bioRxiv · Sep 29, 2020Bioengineering

An acoustic platform for single-cell, high-throughput measurements of the viscoelastic properties of cells

V. Romanov, G. Silvani, H. Zhu, C. D. Cox, B. Martinac

This paper introduces an acoustic platform for high-throughput measurement of viscoelastic properties in adherent cells, showing temperature and pharmacological treatment effects on cell mechanics.

bioRxiv · Sep 7, 2020Bioengineering

Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells

M. Yao, A. S. Tijore, D. Cheng, J. V. Li, A. Hariharan, B. Martinac, G. Tran Van Nhieu, C. D. Cox, M. Sheetz

The paper shows Piezo1 binds to matrix adhesions in a force-dependent manner in normal cells, promoting adhesion maturation and calcium entry, but not in tumor cells.

bioRxiv · Mar 9, 2020Cell Biology

Membrane stiffness is a key determinant of E coli MscS channel mechanosensitivity

F. Xue, C. D. Cox, N. Bavi, P. R. Rohde, Y. Nakayama, B. Martinac

This study shows that membrane stiffness significantly affects the mechanosensitivity of E. coli MscS channels by altering tension response curves and reactivation behavior.

bioRxiv · Oct 4, 2019 · PreprintBiophysics

Piezo1 Induces Local Curvature in a Mammalian Membrane and Forms Specific Protein-Lipid Interactions

A. Buyan, C. Cox, J. Rae, J. Barnoud, J. Li, J. Cvetovska, M. Bastiani, H. S. Chan, M. P. Hodson, B. Martinac, R. G. Parton, S.-J. Marrink, B. Corry

This study shows Piezo1 induces membrane curvature and forms specific lipid interactions, influencing both membrane morphology and lipid composition.

bioRxiv · Sep 30, 2019 · PreprintBiophysics

Disruption of membrane cholesterol organization impairs the concerted activity of PIEZO1 channel clusters

P. Ridone, E. Pandzic, M. Vassalli, C. D. Cox, A. Macmillan, P. A. Gottlieb, B. Martinac

This study shows that membrane cholesterol organization is critical for PIEZO1 channel cluster function, affecting their response to mechanical force and synchronization.

bioRxiv · Apr 11, 2019Biophysics