L. Pei

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Aggresomes protect mRNA under stress in Escherichia coli

The paper shows that aggresomes in E. coli store mRNA under stress, aiding rapid recovery by protecting mRNA from degradation and facilitating translation reactivation.

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques

This study shows that hematopoietic stem cells continuously replenish tissue-resident macrophages in healthy adult macaques, challenging the notion that all macrophages are derived from yolk sac cells.

Life-course social disparities in body mass index trajectories across adulthood: cohort study evidence from China Health and Nutrition Survey

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

The ectromelia virus virulence factor C15 facilitates early viral spread by inhibiting NK cell-infected cell contacts

This study identifies C15 as a poxvirus protein that inhibits NK cell cytolytic function, promoting viral spread by blocking NK cell contact with infected cells.

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

New insights into colorectal cancer liver metastasis carcinogenesis and its effect with moxibustion

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

A phylotranscriptome study using silica gel-dried leaf tissues produces an updated robust phylogeny of Ranunculaceae

This study uses silica-dried leaf tissues for RNA-seq and phylotranscriptomic analysis, showing they are viable for phylogenomic studies with results comparable to liquid nitrogen-preserved samples.

Renal proximal tubule cell state and metabolism are coupled by nuclear receptors

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.