J. Bao

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via caspase BmICE

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

Multi-omics data integration reveals molecular mechanisms of carfilzomib resistance in multiple myeloma

This study identifies molecular mechanisms of carfilzomib resistance in multiple myeloma using multi-omics data from cell lines and patient samples, revealing potential drug combinations to overcome resistance.

MoLst8 regulates autophagy and lipid homeostasis in Magnaporthe oryzae

This study investigates the role of MoLst8 in autophagy and lipid homeostasis in Magnaporthe oryzae, showing its positive regulation of TORC1 and disruption of lipid metabolism in a knockout mutant.

Automated Cytometric Gating with Human-Level Performance Using Bivariate Segmentation

This paper introduces UNITO, a deep learning framework for automated cytometric gating that matches human performance and provides interpretable results without requiring manual input.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Patient-derived functional immuno-oncology platform identifies responders to ATR inhibitor and immunotherapy combinations in ovarian cancer

Nature AND Nurture: Enabling formate-dependent growth in Methanosarcina acetivorans

This study enables formate-dependent methanogenesis in Methanosarcina acetivorans through metabolic engineering and adaptive evolution, expanding its substrate utilization capabilities.

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

The paper identifies osteosarcoma-enriched transcripts that encode extracellular tumor-suppressing proteins, suggesting a paradoxical therapeutic strategy using OS transcriptomes.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Development of an adenosquamous carcinoma histopathology-selective lung cancer graft model

This paper develops a lung cancer graft model that recapitulates histopathology-specific tumor phenotypes and demonstrates histopathology-selective phenotypic dominance over genetic drivers.

Tracing back primed resistance in cancer via sister cells

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

Efficient CRISPR/Cas12a-based genome editing toolbox for metabolic engineering in Methanococcus maripaludis

This paper develops a CRISPR/Cas12a-based genome editing toolbox for Methanococcus maripaludis, achieving high knockout efficiency and enabling metabolic engineering.

Comprehensive RNA-Seq Reveals Molecular Changes in Kidney Malignancy Among People Living with HIV

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal

DrugComb updates its repository and analysis tools to include more comprehensive drug combination and monotherapy data, enhanced algorithms, network modeling, and machine learning models for predicting drug sensitivity and synergy.

The role of SOX9 in non-small cell lung cancer progression is histopathology-selective.

This study shows SOX9 has different roles in NSCLC progression depending on histopathology, promoting papillary adenocarcinoma but suppressing squamous metastasis.

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

This study uses fresh uncultured lung tumor cells to assess drug responses and guide personalized treatment, showing clinical benefit in a refractory cancer case.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Mico-Community associated with ectomycorrhizal Russula symbiosis and sporocarp-producing Russula in Fagaceae dominant nature areas in southern China

The study identifies microbial communities associated with ECM Russula symbiosis and sporocarp production in Fagaceae plants in southern China.

Bayogenin 3-O-Cellobioside is a novel non-cultivar specific anti-blast metabolite produced in rice in response to Pyricularia oryzae infection

The paper identifies Bayogenin 3-O-Cellobioside as a novel anti-blast metabolite in rice, showing a correlation with blast resistance across different cultivars.

Distribution Pattern and Diversity Maintenance Mechanism of the Denitrifier Community in Alkaline Copper Mine Drainage

This study examines how alkaline copper mine drainage affects denitrifier community composition and diversity in a tailings reservoir, finding that environmental factors drive community structure and diversity patterns.

Baculovirus utilizes cholesterol transporter Niemann-Pick C1 for host cell entry

This study identifies BmNPC1 as a critical host receptor for baculovirus infection, showing its interaction with the viral glycoprotein gp64 and role in endosomal fusion.