Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2
C. Li, H. Zhou, L. Guo, D. Xie, H. He, H. Zhang, Y. Liu, L. Peng, L. Zheng, W. Lu, Y. Mei, Z. Liu, J. Huang, M. Wang, D. Shu, , C.-N. Qian
This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.
bioRxiv · Dec 14, 2021Pharmacology & Toxicology