Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
S. Sun, Y. Cai, T.-Z. Song, Y. Pu, L. Cheng, H. Xu, C. Meng, Y. Lin, J. Sun, S. Zhang, Y. Gao, J.-B. Han, X.-L. Feng, D.-D. Yu, Y. Zhu, , H. Peng
This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.
bioRxiv · May 12, 2021Immunology