Transcription regulation of SARS-CoV-2 receptor ACE2 by Sp1: a potential therapeutic target
H. Han, R.-H. Luo, X.-Y. Long…·C.-g. Zou
This study identifies Sp1 as a regulator of ACE2 expression in response to SARS-CoV-2 infection and shows that targeting Sp1 reduces viral replication and tissue injury in Syrian hamsters.