Y. Ju

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

A CRISPR-Nonhomologous End-Joining-based strategy for rapid and efficient gene disruption in Mycobacterium abscessus

This paper introduces a CRISPR-NHEJ strategy for efficient gene disruption in Mycobacterium abscessus and shows that homologous recombination and single-strand annealing components are required for NHEJ repair.

The evolution of two transmissible leukaemias colonizing the coasts of Europe

This study investigates the origin and evolution of two transmissible leukaemias in common cockles, identifying clonal origins, mutational signatures, and genomic instability.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies

The paper develops a 3D workflow to analyze multiplexed skin biopsy data, revealing age-related changes in DNA repair and immune cell ratios.

TopoRoot: A method for computing hierarchy and fine-grained traits of maize roots from X-ray CT images

TopoRoot computes fine-grained root traits from maize root CT images, improving accuracy over existing methods and enabling automated analysis of root system architecture.

Three bacterium-plasmid golden combinations facilitate the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

Visualizing cancer-originated acetate uptake through MCT1 in reactive astrocytes demarcates tumor border and extends survival in glioblastoma patients

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

Alisertib exerts KRAS allele specific anticancer effects in colorectal cancer

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

Pollen tube-triggered accumulation of NORTIA at the filiform apparatus facilitates fertilization in Arabidopsis thaliana

The paper shows that NORTIA accumulation at the filiform apparatus is essential for pollen tube reception in Arabidopsis thaliana.

Shotgun Metagenomics of 361 elderly women reveals gut microbiome change in bone mass loss

This study analyzes gut microbiome data from 361 elderly women to explore its association with bone mass loss and bone mineral density.

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

Life history recorded in the vagino-cervical microbiome

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

Inhibiting Mycobacterium tuberculosis ClpP1P2 by addressing the equatorial handle domain of ClpP1 subunit

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.