Q. Liang

Microbial single-cell omics in situ

The paper reports a method using LIFT technology to obtain high-quality microbial single-cell genomes or transcriptomes from complex samples and demonstrates its application to study cell-fate commitment in sporulation.

The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.

An Engineered IGF2 Mutant for Lysosomal Targeting Chimeras Development and Membrane Proteins Degradation

This paper introduces eiLYTACs, an engineered IGF2-based technology that degrades membrane proteins and inhibits tumor growth by avoiding IGF1R activation.

Architecture and infection-sensing mechanism of the bacterial PARIS defense system

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

An automated archival single-nucleus total RNA sequencing platform mapping integrative and retrospective cell atlas of gliomas

This paper introduces an automated single-nucleus RNA sequencing platform for analyzing archival glioma samples, revealing molecular characteristics and recurrence-related targets.

Evolution of novel sensory organs in fish with legs

The paper investigates how sea robins evolved leg-like sensory organs for prey detection, showing papillae enable enhanced mechanical and chemical sensing for predatory behavior.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

MolPhase: An Advanced Phase Separation Predictor and an Investigation of Phytobacterial Effector in Plant

MolPhase predicts protein phase separation using physicochemical features and experimental data, showing T3Es undergo homotypic phase separation in vitro and in vivo.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.

This study identifies Zfp697 as a regulator of muscle regeneration and inflammation by mediating interferon gamma signaling and interacting with ncRNAs like miR-206.

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

Metal-driven anaerobic oxidation of methane as an important methane sink in methanic cold seep sediments

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis

The paper identifies a stress-response gene network linked to CD1C-CD141 dendritic cells that correlates with prognosis in burns and COVID-19.

Hydroxycitric acid inhibits oxalate nephropathies formation through crystallization regulation and activation of the PPARα pathway

This study shows hydroxycitric acid inhibits oxalate nephropathies by reducing calcium oxalate crystal deposition and activating the PPARα pathway.

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Comparative miRNA Transcriptomics of Mouse and Macaque Reveals MYOC is An Inhibitor for C. neoformans Invasion into Brain

Tomato SlBES1.8 influences leaf morphogenesis by mediating gibberellin metabolism and signaling

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells

ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson's disease

This study identifies GardeninA as a neuroprotective compound against paraquat-induced Parkinson's in Drosophila, showing effects beyond antioxidant activity.

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

The natural compound Notopterol targets JAK2/3 to ameliorate macrophage-induced inflammation and arthritis

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression.

This paper develops an antibody targeting ICOS that improves the TEFF:TReg ratio and induces tumour regression in preclinical models.